Costimulation: critical pathways in the immunologic regulation of asthma (Q36026037)

11 August 2017

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title

Costimulation: critical pathways in the immunologic regulation of asthma (English)

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11 August 2017

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Abdelouahab Bellou

1

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PubMed ID

15683616

11 August 2017

Patricia W Finn

series ordinal

2

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11 August 2017

1 March 2005

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Current Allergy and Asthma Reports

11 August 2017

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11 August 2017

5

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11 August 2017

2

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11 August 2017

149-154

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https://scigraph.springernature.com/pub.10.1007/s11882-005-0089-6

11 August 2017

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ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses

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Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

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CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

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B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

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B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness

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Costimulation of T cells by OX40, 4-1BB, and CD27.

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Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma

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CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL

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12 December 2020

Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor

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12 December 2020

CTLA-4 is a second receptor for the B cell activation antigen B7

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12 December 2020

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12 December 2020

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12 December 2020

Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness

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Toll-like receptor 4 or 2 agonists decrease allergic inflammation.

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12 December 2020

10.1007/S11882-005-0089-6

Identifiers

DOI

1 reference

11 August 2017

1 reference

PubMed ID

15683616