Current status of treatment of spinal and bulbar muscular atrophy. (Q36037644)

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Current status of treatment of spinal and bulbar muscular atrophy (English)

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2 October 2017

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Molecular pathophysiology and disease-modifying therapies for spinal and bulbar muscular atrophy.

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

23 September 2018

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Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

23 September 2018

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

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Late onset of obesity in male androgen receptor-deficient (AR KO) mice

23 September 2018

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23 September 2018

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

23 September 2018

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Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

23 September 2018

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Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

23 September 2018

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Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

23 September 2018

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A Comprehensive Endocrine Description of Kennedy's Disease Revealing Androgen Insensitivity Linked to CAG Repeat Length

23 September 2018

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Androgen Receptor (AR) Coregulators: An Overview

21 January 2018

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Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity

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Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

21 January 2018

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12 December 2020

Polyglutamine and CBP: fatal attraction?

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Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

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12 December 2020

Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy

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12 December 2020

Differential pattern in tissue-specific somatic mosaicism of expanded CAG trinucleotide repeats in dentatorubral-pallidoluysian atrophy, Machado-Joseph disease, and X-linked recessive spinal and bulbar muscular atrophy

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Founder effect in spinal and bulbar muscular atrophy (SBMA)

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Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance

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Dutasteride for spinal and bulbar muscular atrophy

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Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain

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Identifiers

DOI

10.1155/2012/369284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22720173%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22720173%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22720173

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22720173%20AND%20SRC:MED&resulttype=core&format=json