Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein (Q36495265)

14 August 2017

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title

Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein (English)

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14 August 2017

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7

Gen Sobue

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14 August 2017

Masahiro Waza

1

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14 August 2017

Hiroaki Adachi

2

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14 August 2017

Masahisa Katsuno

3

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14 August 2017

Makoto Minamiyama

4

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14 August 2017

Fumiaki Tanaka

5

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14 August 2017

Manabu Doyu

6

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14 August 2017

2 June 2006

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Journal of Molecular Medicine

14 August 2017

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14 August 2017

84

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14 August 2017

8

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14 August 2017

635-646

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https://scigraph.springernature.com/pub.10.1007/s00109-006-0066-0

14 August 2017

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cites work

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Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

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Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

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Modulation of Akt kinase activity by binding to Hsp90

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12 December 2020

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

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12 December 2020

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

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12 December 2020

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

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12 December 2020

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Induction of hsp 72/73 by herbimycin A, an inhibitor of transformation by tyrosine kinase oncogenes.

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12 December 2020

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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12 December 2020

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

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12 December 2020

Inefficient degradation of truncated polyglutamine proteins by the proteasome

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12 December 2020

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

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12 December 2020

Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

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12 December 2020

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

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12 December 2020

Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.

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12 December 2020

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

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12 December 2020

Geldanamycin provides posttreatment protection against glutamate-induced oxidative toxicity in a mouse hippocampal cell line

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12 December 2020

Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.

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12 December 2020

Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor

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Targeting toxic proteins for turnover

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12 December 2020

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

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12 December 2020

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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12 December 2020

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

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12 December 2020

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

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12 December 2020

IKK mediates ischemia-induced neuronal death

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12 December 2020

Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila.

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12 December 2020

Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear pa

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12 December 2020

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

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12 December 2020

Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells

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12 December 2020

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

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12 December 2020

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

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12 December 2020

Nucleotides and two functional states of hsp90

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12 December 2020

A phase II trial of 17-allylamino-17- demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

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12 December 2020

Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: a pathogenic marker

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12 December 2020

Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

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12 December 2020

Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin Vivo

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12 December 2020

Hsp90 inhibitors as novel cancer chemotherapeutic agents

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12 December 2020

X-linked recessive bulbospinal neuronopathy. A clinicopathological study

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12 December 2020

Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein

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12 December 2020

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

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12 December 2020

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

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12 December 2020

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

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12 December 2020

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

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12 December 2020

Binding of p23 and hsp90 during assembly with the progesterone receptor

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12 December 2020

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

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12 December 2020

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

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12 December 2020

Protein aggregation and neurodegenerative disease

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12 December 2020

Animal models of Kennedy disease

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12 December 2020

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

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12 December 2020

Cellular survival: a play in three Akts

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12 December 2020

Implications of heat shock/stress proteins for medicine and disease.

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12 December 2020

Therapeutics development for triplet repeat expansion diseases

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12 December 2020

Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).

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12 December 2020

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

Cancer: the rules of attraction

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12 December 2020

High-throughput screening for Hsp90 ATPase inhibitors

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12 December 2020

Chaperones increase association of tau protein with microtubules

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12 December 2020

Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation

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12 December 2020

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system

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12 December 2020

Founder effect in spinal and bulbar muscular atrophy (SBMA)

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12 December 2020

Geldanamycin specifically modulates thrombin-mediated morphological changes in mouse neuroblasts

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12 December 2020

Emerging role for ERK as a key regulator of neuronal apoptosis

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12 December 2020

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

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12 December 2020

Heat shock protein 90 inhibition by 17-allylamino-17- demethoxygeldanamycin: a novel therapeutic approach for treating hormone-refractory prostate cancer.

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12 December 2020

Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation.

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12 December 2020

Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons

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12 December 2020

Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus

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12 December 2020

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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12 December 2020

p23, a simple protein with complex activities

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12 December 2020

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

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12 December 2020

Therapeutic and diagnostic implications of Hsp90 activation

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12 December 2020

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

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12 December 2020

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition

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12 December 2020

Geldanamycin reduces necrotic and apoptotic injury due to oxygen-glucose deprivation in astrocytes.

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12 December 2020

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

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12 December 2020

Structure, function, and mechanism of the Hsp90 molecular chaperone

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12 December 2020

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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12 December 2020

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

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12 December 2020

Modulation of neurodegeneration by molecular chaperones

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12 December 2020

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

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12 December 2020

Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene

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12 December 2020

The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

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12 December 2020

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

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12 December 2020

The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons.

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12 December 2020

Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways

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12 December 2020

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

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12 December 2020

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

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12 December 2020

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

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12 December 2020

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

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12 December 2020

Effect of geldanamycin on androgen receptor function and stability

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12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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12 December 2020

A cell-based screen for modulators of ataxin-1 phosphorylation

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12 December 2020

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.

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12 December 2020

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

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12 December 2020

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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12 December 2020

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

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12 December 2020

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

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12 December 2020

Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis

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12 December 2020

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

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12 December 2020

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

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12 December 2020

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death

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12 December 2020

EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

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12 December 2020

Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers

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12 December 2020

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

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12 December 2020

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

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12 December 2020

Pharmacological prevention of Parkinson disease in Drosophila.

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12 December 2020

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

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12 December 2020

Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives

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12 December 2020

Heat shock protein 90 indirectly regulates ERK activity by affecting Raf protein metabolism

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12 December 2020

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

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12 December 2020

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

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12 December 2020

Geldanamycin, a new antibiotic

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12 December 2020

Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity

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12 December 2020

ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3.

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12 December 2020

10.1007/S00109-006-0066-0

Identifiers

DOI

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14 August 2017

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