Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity (Q36040443)

11 August 2017

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity (English)

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11 August 2017

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Brian K Kennedy

11

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author name string

Shihyin Tsai

1

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11 August 2017

Joanna M Sitzmann

2

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11 August 2017

Somasish G Dastidar

3

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11 August 2017

Ariana A Rodriguez

4

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11 August 2017

Stephanie L Vu

5

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11 August 2017

Circe E McDonald

6

1 reference

11 August 2017

Emmeline C Academia

7

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11 August 2017

Monique N O'Leary

8

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11 August 2017

Travis D Ashe

9

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11 August 2017

Albert R La Spada

10

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11 August 2017

language of work or name

English

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publication date

29 June 2015

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Journal of Clinical Investigation

11 August 2017

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11 August 2017

125

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11 August 2017

8

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11 August 2017

2952-2964

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describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4563739/fullTextXML

inferred from PubMed Central ID database lookup

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2 October 2017

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A unifying model for mTORC1-mediated regulation of mRNA translation.

2 October 2017

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Rapid determination of myosin heavy chain expression in rat, mouse, and human skeletal muscle using multicolor immunofluorescence analysis

2 October 2017

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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The metabolic footprint of aging in mice

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

2 October 2017

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

2 October 2017

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Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function.

2 October 2017

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Forming functional fat: a growing understanding of adipocyte differentiation

2 October 2017

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Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy

2 October 2017

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The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism?

2 October 2017

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Cellular bioenergetics as a target for obesity therapy

2 October 2017

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2 October 2017

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Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

2 October 2017

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2 October 2017

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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

2 October 2017

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4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

2 October 2017

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

2 October 2017

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

2 October 2017

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The TOR pathway comes of age

2 October 2017

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Identification and importance of brown adipose tissue in adult humans

2 October 2017

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Molecular mechanisms of mTOR-mediated translational control

2 October 2017

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mTOR and the control of whole body metabolism

2 October 2017

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

2 October 2017

1 reference

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Fibroblast growth factor 21 corrects obesity in mice

2 October 2017

1 reference

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Longevity genomics across species.

2 October 2017

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Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice

2 October 2017

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Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance

2 October 2017

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Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

2 October 2017

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

2 October 2017

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Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle

2 October 2017

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2 October 2017

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Sarcopenia of aging and its metabolic impact

2 October 2017

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Metabolic control through the PGC-1 family of transcription coactivators

2 October 2017

1 reference

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Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse

2 October 2017

1 reference

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Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.

2 October 2017

1 reference

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Regulation of muscle fiber type and running endurance by PPARdelta

2 October 2017

1 reference

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Upstream and downstream of mTOR

2 October 2017

1 reference

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2 October 2017

1 reference

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563739

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

2 October 2017

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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

2 October 2017

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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

2 October 2017

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

2 October 2017

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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

2 October 2017

1 reference

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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2 October 2017

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

2 October 2017

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FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging

2 October 2017

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Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

11 July 2018

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Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

11 July 2018

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Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

11 July 2018

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Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice.

11 July 2018

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Skeletal muscle mass and risk of death in an elderly population

11 July 2018

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mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

23 September 2018

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Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease.

23 September 2018

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Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.

23 September 2018

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Autophagy is required to maintain muscle mass.

23 September 2018

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SUnSET, a nonradioactive method to monitor protein synthesis.

23 September 2018

1 reference

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S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.

23 September 2018

1 reference

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Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control

23 September 2018

1 reference

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Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

23 September 2018

1 reference

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A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

23 September 2018

1 reference

12 December 2020

Measurement of proton leak and electron leak in isolated mitochondria

1 reference

12 December 2020

Intracellular signaling specificity in skeletal muscle in response to different modes of exercise

1 reference

12 December 2020

Aging and glucose homeostasis in C57BL/6J male mice

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI77361

1 reference

11 August 2017

1 reference

11 August 2017

1 reference