Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. (Q36068699)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

review article

1 reference

title

Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Shufeng Zhou

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Sui Yung Chan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Boon Cher Goh

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Wei Duan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Min Huang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Howard L McLeod

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

publication date

1 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacokinetics

9 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

279-304

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15762770%20AND%20SRC:MED&resulttype=core&format=json

Kinetics of suicide substrates

9 January 2020

cites work

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200544030-00005

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

21 January 2018

1 reference

12 December 2020

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

1 reference

12 December 2020

Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions

1 reference

12 December 2020

Influence of gestodene and desogestrel as components of low-dose oral contraceptives on the pharmacokinetics of ethinyl estradiol (EE2), on serum CBG and on urinary cortisol and 6 beta-hydroxycortisol.

1 reference

12 December 2020

Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone

1 reference

12 December 2020

Cytochrome P-450-dependent oxidation of the 17 alpha-ethynyl group of synthetic steroids. D-homoannulation or enzyme inactivation

1 reference

12 December 2020

Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation

1 reference

12 December 2020

Covalent bonding of the prosthetic heme to protein: a potential mechanism for the suicide inactivation or activation of hemoproteins

1 reference

12 December 2020

Metabolite inhibition of parent drug biotransformation. Studies of diltiazem.

1 reference

12 December 2020

Concentrations and effects of zopiclone are greatly reduced by rifampicin

1 reference

12 December 2020

Clinically significant pharmacokinetic drug interactions with carbamazepine. An update

1 reference

12 December 2020

Triazolam is ineffective in patients taking rifampin

1 reference

12 December 2020

Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites

1 reference

12 December 2020

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

1 reference

12 December 2020

Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily.

1 reference

12 December 2020

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation

1 reference

12 December 2020

Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.

1 reference

12 December 2020

Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites

1 reference

12 December 2020

Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A

1 reference

12 December 2020

Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity

1 reference

12 December 2020

Kinetics of suicide substrates. Practical procedures for determining parameters

1 reference

12 December 2020

Decrease in a constitutive form of cytochrome P-450 by macrolide antibiotics

1 reference

12 December 2020

Pharmacokinetic drug interactions of macrolides

1 reference

12 December 2020

Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers

1 reference

12 December 2020

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

1 reference

12 December 2020

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

1 reference

12 December 2020

(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6.

1 reference

12 December 2020

How important are gender differences in pharmacokinetics?

1 reference

12 December 2020

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

1 reference

12 December 2020

Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains

1 reference

12 December 2020

Calcium channel antagonists and cyclosporine metabolism: in vitro studies with human liver microsomes

1 reference

12 December 2020

A potentially hazardous interaction between erythromycin and midazolam.

1 reference

12 December 2020

Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism

1 reference

12 December 2020

Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione

1 reference

12 December 2020

Early postoperative erythromycin breath test correlates with hepatic cytochrome P4503A activity in liver transplant recipients

1 reference

12 December 2020

N-oxidative transformation of free and N-substituted amine functions by cytochrome P450 as means of bioactivation and detoxication

1 reference

12 December 2020

Metabolism of 17 alpha-ethynylestradiol in humans

1 reference

12 December 2020

The mechanism of cyclosporine toxicity induced by clarithromycin

1 reference

12 December 2020

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily

1 reference

12 December 2020

Comparison of the effects of the new azalide antibiotic, azithromycin, and erythromycin estolate on rat liver cytochrome P-450

1 reference

12 December 2020

The steady-state disposition of indinavir is not altered by the concomitant administration of clarithromycin

1 reference

12 December 2020

The erythromycin breath test for the prediction of drug clearance

1 reference

12 December 2020

Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications

1 reference

12 December 2020

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

1 reference

12 December 2020

Selective inhibitors of cytochromes P450.

1 reference

12 December 2020

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1 reference

12 December 2020

Clarithromycin-carbamazepine interaction: a case report

1 reference

12 December 2020

Macrolide antibacterials. Drug interactions of clinical significance

1 reference

12 December 2020

Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes

1 reference

12 December 2020

Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine.

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interactions between diltiazem and methylprednisolone in healthy volunteers

1 reference

12 December 2020

Cyp3A regulation: from pharmacology to nuclear receptors.

1 reference

12 December 2020

Antiprogestin-mediated inactivation of cytochrome P450 3A4.

1 reference

12 December 2020

Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A

1 reference

12 December 2020

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

1 reference

12 December 2020

Influence of erythromycin on cyclosporine pharmacokinetics

1 reference

12 December 2020

Combination therapy with diltiazem and nifedipine in patients with effort angina pectoris

1 reference

12 December 2020

Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes

1 reference

12 December 2020

The effect of multiple doses of ritonavir on the pharmacokinetics of rifabutin

1 reference

12 December 2020

Orphan nuclear receptors: the exotics of xenobiotics.

1 reference

12 December 2020

Identification of an inducible form of cytochrome P-450 in human liver

1 reference

12 December 2020

In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.

1 reference

12 December 2020

The importance of drug interactions in epilepsy therapy

1 reference

12 December 2020

Inhibition of alfentanil metabolism by erythromycin.

1 reference

12 December 2020

Characterization of rat cytochrome P450 isozymes involved in the covalent binding of cyclosporin A to microsomal proteins

1 reference

12 December 2020

Differential impairment of triazolam and zolpidem clearance by ritonavir

1 reference

12 December 2020

Pharmacokinetics and safety of amprenavir and ritonavir following multiple-dose, co-administration to healthy volunteers

1 reference

12 December 2020

Elucidation of the structural requirements for the bioactivation of mianserin in-vitro

1 reference

12 December 2020

Topological alteration of the CYP3A4 active site by the divalent cation Mg(2+).

1 reference

12 December 2020

Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes

1 reference

12 December 2020

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

1 reference

12 December 2020

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity

1 reference

12 December 2020

Fetus-specific expression of a form of cytochrome P-450 in human livers

1 reference

12 December 2020

Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity

1 reference

12 December 2020

Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed.

1 reference

12 December 2020

Characterization of the selectivity and mechanism of human cytochrome P450 inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate

1 reference

12 December 2020

Inactivation of cytochrome P450 by the food-derived complex phenol oleuropein

1 reference

12 December 2020

The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function.

1 reference

12 December 2020

Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates.

1 reference

12 December 2020

Kinetics of suicide substrates. Steady-state treatments and computer-aided exact solutions.

1 reference

12 December 2020

Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass grafting.

1 reference

12 December 2020

Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers

1 reference

12 December 2020

Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors

1 reference

12 December 2020

Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates.

1 reference

12 December 2020

Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine.

1 reference

12 December 2020

Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes

1 reference

12 December 2020

Mechanism-Based Inactivation of Hepatic Ethoxyresorufin O-Dealkylation Activity by Naturally Occurring Coumarins

1 reference

12 December 2020

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

1 reference

12 December 2020

Cardiovascular drug-drug interactions

1 reference

12 December 2020

Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes

1 reference

12 December 2020

Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs.

1 reference

12 December 2020

Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds

1 reference

12 December 2020

Role of P-glycoprotein in pharmacokinetics: clinical implications

1 reference

12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

12 December 2020

Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.

1 reference

12 December 2020

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes

1 reference

12 December 2020

Cytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agents

1 reference

12 December 2020

Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes

1 reference

12 December 2020

Inhibition of methylprednisolone elimination in the presence of clarithromycin therapy.

1 reference

12 December 2020

Terfenadine-antidepressant interactions: an in vitro inhibition study using human liver microsomes

1 reference

12 December 2020

Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450.

1 reference

12 December 2020

Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers

1 reference

12 December 2020

Progress in predicting human ADME parameters in silico

1 reference

12 December 2020

Interaction between erythromycin and nitrazepam in healthy volunteers

1 reference

12 December 2020

Effect of age and gender on the activity of human hepatic CYP3A

1 reference

12 December 2020

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

1 reference

12 December 2020

Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole

1 reference

12 December 2020

Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6.

1 reference

12 December 2020

Summary of information on human CYP enzymes: human P450 metabolism data

1 reference

12 December 2020

Dose-dependent inhibition of CYP3A activity by clarithromycin during Helicobacter pylori eradication therapy assessed by changes in plasma lansoprazole levels and partial cortisol clearance to 6beta-hydroxycortisol

1 reference

12 December 2020

In vitro approaches to predicting drug interactions in vivo.

1 reference

12 December 2020

Analysis of midazolam and metabolites in plasma by high-performance liquid chromatography: probe of CYP3A.

1 reference

12 December 2020

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

1 reference

12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1 reference

12 December 2020

Effects of macrolide antibiotics on CYP3A expression in human and rat hepatocytes: interspecies differences in response to troleandomycin.

1 reference

12 December 2020

Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences

1 reference

12 December 2020

Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors

1 reference

12 December 2020

Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase

1 reference

12 December 2020

Bioactivation of 8-methoxypsoralen and irreversible inactivation of cytochrome P-450 in mouse liver microsomes: modification by monoclonal antibodies, inhibition of drug metabolism and distribution of covalent adducts.

1 reference

12 December 2020

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1 reference

12 December 2020

Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine.

1 reference

12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

12 December 2020

Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

1 reference

12 December 2020

New high-performance liquid chromatographic method for the determination of alprazolam and its metabolites in serum: instability of 4-hydroxyalprazolam

1 reference

12 December 2020

Transient-phase kinetics of enzyme inactivation induced by suicide substrates.

1 reference

12 December 2020

Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations

1 reference

12 December 2020

Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s.

1 reference

12 December 2020

Development of a generalized, quantitative physicochemical model of CYP3A4 inhibition for use in early drug discovery

1 reference

12 December 2020

Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase

1 reference

12 December 2020

Reversal of multidrug resistance by RU 486.

1 reference

12 December 2020

Urinary 6 beta-hydroxycortisol/cortisol ratios measured by high-performance liquid chromatography for use as a biomarker for the human cytochrome P-450 3A4

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interactions between diltiazem and quinidine.

1 reference

12 December 2020

Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation

1 reference

12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

12 December 2020

Molecular modeling of human cytochrome P450-substrate interactions

1 reference

12 December 2020

In vitro and pharmacophore insights into CYP3A enzymes

1 reference

12 December 2020

Pharmacokinetic interaction between cyclosporin and diltiazem

1 reference

12 December 2020

Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily

1 reference

12 December 2020

Prediction of potential toxicity and side effect protein targets of a small molecule by a ligand-protein inverse docking approach

1 reference

12 December 2020

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

1 reference

12 December 2020

Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients.

1 reference

12 December 2020

Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein

1 reference

12 December 2020

Cytochrome P-450 3A4: regulation and role in drug metabolism

1 reference

12 December 2020

Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice

1 reference

12 December 2020

Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites

1 reference

12 December 2020

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

1 reference

12 December 2020

Dose of midazolam should be reduced during diltiazem and verapamil treatments

1 reference

12 December 2020

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole

1 reference

12 December 2020

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

1 reference

12 December 2020

The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1).

1 reference

12 December 2020

1 reference

12 December 2020

Can oral contraceptive steroids influence the elimination of nifedipine and its primary pryidine metabolite in humans?

1 reference

12 December 2020

Prediction of midazolam-CYP3A inhibitors interaction in the human liver from in vivo/in vitro absorption, distribution, and metabolism data.

1 reference

12 December 2020

The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron

1 reference

12 December 2020

1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes

1 reference

12 December 2020

Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.

1 reference

12 December 2020

In vitro and in vivo drug interactions involving human CYP3A.

1 reference

12 December 2020

Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir

1 reference

12 December 2020

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site

1 reference

12 December 2020

Norethisterone and ethinyl estradiol kinetics during dapsone therapy

1 reference

12 December 2020

Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A

1 reference

12 December 2020

Mechanism-based inactivators as probes of cytochrome P450 structure and function

1 reference

12 December 2020

Low-dose ritonavir for protease inhibitor pharmacokinetic enhancement

1 reference

12 December 2020

Pharmacokinetic pharmacodynamic evaluation of the combined administration of alprazolam and fluoxetine

1 reference

12 December 2020

In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices

1 reference

12 December 2020

Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects

1 reference

12 December 2020

Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors

1 reference

12 December 2020

Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions

1 reference

12 December 2020

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction

1 reference

12 December 2020

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

12 December 2020

Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters

1 reference

12 December 2020

Liver function and phase I drug metabolism in the elderly: a paradox

1 reference

12 December 2020

Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?

1 reference

12 December 2020

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4

1 reference

12 December 2020

Cumene hydroperoxide-mediated inactivation of cytochrome P450 2B1. Identification of an active site heme-modified peptide

1 reference

12 December 2020

Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations

1 reference

12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

1 reference

12 December 2020

N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity

1 reference

12 December 2020

Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro.

1 reference

12 December 2020

A clinical study investigating the pharmacokinetic interaction between NN703 (tabimorelin), a potential inhibitor of CYP3A4 activity, and midazolam, a CYP3A4 substrate

1 reference

12 December 2020

Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides

1 reference

12 December 2020

Pharmacokinetic interactions of the macrolide antibiotics

1 reference

12 December 2020

Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions

1 reference

12 December 2020

Further studies of the suicide inactivation of purified rat liver cytochrome P-450 by chloramphenicol

1 reference

12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

12 December 2020

Interaction between erythromycin and the benzodiazepines diazepam and flunitrazepam.

1 reference

12 December 2020

Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath test

1 reference

12 December 2020

Molecular modeling of cytochrome P450 3A4

1 reference

12 December 2020

Pharmacokinetic interaction between ritonavir and clarithromycin

1 reference

12 December 2020

Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.

1 reference

12 December 2020

Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.

1 reference

12 December 2020

The interaction of diltiazem with lovastatin and pravastatin

1 reference

12 December 2020

Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship

1 reference

12 December 2020

Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors

1 reference

12 December 2020

Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl

1 reference

12 December 2020

Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity

1 reference

12 December 2020

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

1 reference

12 December 2020

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

1 reference

12 December 2020

Steady-state pharmacokinetics of amprenavir coadministered with ritonavir in human immunodeficiency virus type 1-infected patients

1 reference

12 December 2020

Possible inhibition of hepatic metabolism of quinidine by erythromycin

1 reference

12 December 2020

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

1 reference

12 December 2020

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

1 reference

12 December 2020

Drug interactions with cisapride: clinical implications

1 reference

12 December 2020

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease

1 reference

12 December 2020

Effects of erythromycin on hepatic drug-metabolizing enzymes in humans

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

1 reference

12 December 2020

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

1 reference

12 December 2020

Determination of testosterone and 6beta-hydroxytestosterone by gas chromatography-selected ion monitoring-mass spectrometry for the characterization of cytochrome p450 3A activity

1 reference

12 December 2020

Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.

1 reference

12 December 2020

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4.

1 reference

12 December 2020

Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals

1 reference

12 December 2020

Metabolism of delavirdine, a human immunodeficiency virus type-1 reverse transcriptase inhibitor, by microsomal cytochrome P450 in humans, rats, and other species: probable involvement of CYP2D6 and CYP3A.

1 reference

12 December 2020

Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir

1 reference

12 December 2020

Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4.

1 reference

12 December 2020

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

1 reference

12 December 2020

Selective protein covalent binding and target organ toxicity

1 reference

12 December 2020

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

1 reference

12 December 2020

Effect of troglitazone on urinary excretion of 6beta-hydroxycortisol

1 reference

12 December 2020

Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes

1 reference

12 December 2020

Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen

1 reference

12 December 2020

ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease

1 reference

12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

1 reference

12 December 2020

Present and future in vitro approaches for drug metabolism.

1 reference

12 December 2020

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation

1 reference

12 December 2020

Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance

1 reference

12 December 2020

The influence of midazolam on plasma concentrations and pharmacokinetic parameters of lidocaine in rabbits

1 reference

12 December 2020

Concurrent clarithromycin and cyclosporin A treatment

1 reference

12 December 2020

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

1 reference

12 December 2020

Gas chromatographic-mass spectrometric analysis of alfentanil metabolites. Application to human liver microsomal alfentanil biotransformation.

1 reference

12 December 2020

Investigation of the stereoselective metabolism of the chiral H1-antihistaminic drug terfenadine by high-performance liquid chromatography

1 reference

12 December 2020

Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

1 reference

12 December 2020

Elucidation of distinct ligand binding sites for cytochrome P450 3A4

1 reference

12 December 2020

A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism.

1 reference

12 December 2020

An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.

1 reference

12 December 2020

Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes

1 reference

12 December 2020

Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats

1 reference

12 December 2020

The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.

1 reference

12 December 2020

Active efflux of CPT-11 and its metabolites in human KB-derived cell lines

1 reference

12 December 2020

Interactions between drugs for erectile dysfunction and drugs for cardiovascular disease

1 reference

12 December 2020

Sensitive HPLC for simultaneous quantification of lidocaine and its metabolites monoethylglycinexylidide and glycinexylidide in serum.

1 reference

12 December 2020

Protein targets of xenobiotic reactive intermediates

1 reference

12 December 2020

Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation

1 reference

12 December 2020

Clinical importance of the cytochromes P450

1 reference

12 December 2020

Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450

1 reference

12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

1 reference

12 December 2020

Effect of grapefruit juice on urinary 6 beta-hydroxycortisol/cortisol excretion

1 reference

12 December 2020

Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences

1 reference

12 December 2020

Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery

1 reference

12 December 2020

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450

1 reference

12 December 2020

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

1 reference

12 December 2020

Possible role of the intestinal P-450 enzyme system in a cyclosporine-clarithromycin interaction

1 reference

12 December 2020

Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese: the role of CYP3A.

1 reference

12 December 2020

Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats

1 reference

12 December 2020

Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4

1 reference

12 December 2020

Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis.

1 reference

12 December 2020

A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro

1 reference

12 December 2020

Noninvasive tests of CYP3A enzymes

1 reference

12 December 2020

Assessment of liver metabolic function. Clinical implications

1 reference

12 December 2020

Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models

1 reference

12 December 2020

Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor.

1 reference

12 December 2020

Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats

1 reference

12 December 2020

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

1 reference

12 December 2020

Enhanced effect of triazolam with diltiazem

1 reference

12 December 2020

Carbamazepine neurotoxicity precipitated by diltiazem

1 reference

12 December 2020

In vitro inhibition of simvastatin metabolism, a HMG-CoA reductase inhibitor in human and rat liver by bergamottin, a component of grapefruit juice

1 reference

12 December 2020

Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts.

1 reference

12 December 2020

Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents

1 reference

12 December 2020

Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394.

1 reference

12 December 2020

The influence of cisapride and clarithromycin on QT intervals in healthy volunteers.

1 reference

12 December 2020

Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation

1 reference

12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

1 reference

12 December 2020

Regulation of cyp3a gene transcription by the pregnane x receptor

1 reference

12 December 2020

Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

1 reference

12 December 2020

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

12 December 2020

Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate)

1 reference

12 December 2020

Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions

1 reference

12 December 2020

Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes

1 reference

12 December 2020

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

1 reference

12 December 2020

Monoethylglycinexylidide formation measurement as a hepatic function test to assess severity of chronic liver disease

1 reference

12 December 2020

Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir.

1 reference

12 December 2020

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

1 reference

12 December 2020

Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

1 reference

12 December 2020

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.

1 reference

12 December 2020

Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes

1 reference

12 December 2020

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1 reference

12 December 2020

Application of in silico approaches to predicting drug--drug interactions

1 reference

12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

1 reference

12 December 2020

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

1 reference

12 December 2020

Influence of amiodarone on urinary excretion of 6beta-hydroxycortisol in humans

1 reference

12 December 2020

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

1 reference

12 December 2020

Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes

1 reference

12 December 2020

Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs

1 reference

12 December 2020

Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein

1 reference

12 December 2020

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

1 reference

12 December 2020

In vitro evaluation of the disposition of A novel cysteine protease inhibitor.

1 reference

12 December 2020

Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers

1 reference

12 December 2020

Low-dose ritonavir moderately enhances nelfinavir exposure

1 reference

12 December 2020

Time- and dose-dependent pharmacokinetics of L-754,394, an HIV protease inhibitor, in rats, dogs and monkeys

1 reference

12 December 2020

Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation

1 reference

12 December 2020

Nifedipine: variability in its kinetics and metabolism in man.

1 reference

12 December 2020

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

1 reference

12 December 2020

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin

1 reference

12 December 2020

Fluoxetine impairs clearance of alprazolam but not of clonazepam

1 reference

12 December 2020

Suicide inactivation of cytochrome P-450 by methoxsalen. Evidence for the covalent binding of a reactive intermediate to the protein moiety

1 reference

12 December 2020

Primary aromatic amines: their N-oxidative bioactivation

1 reference

12 December 2020