Summary of information on human CYP enzymes: human P450 metabolism data (Q32103802)

6 July 2017

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title

Summary of information on human CYP enzymes: human P450 metabolism data (English)

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6 July 2017

Slobodan Rendic

1

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6 July 2017

language of work or name

English

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publication date

1 February 2002

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6 July 2017

published in

Drug Metabolism Reviews

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6 July 2017

volume

34

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6 July 2017

issue

1-2

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6 July 2017

page(s)

83-448

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Human cytochrome P-450 enzymes

6 July 2017

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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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Measurement of liver microsomal cytochrome p450 (CYP2D6) activity using [O-methyl-14C]dextromethorphan

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Quinupristin-dalfopristin: an overview

21 January 2018

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Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections

21 January 2018

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Safety and tolerability of quinupristin/dalfopristin: administration guidelines

21 January 2018

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Study of coumarin metabolism by Chinese hamster lung fibroblasts expressing a human cytochrome P450 using H-nmr

21 January 2018

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Genetic implications in the metabolism and toxicity of mycotoxins

21 January 2018

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Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

21 January 2018

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Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene.

21 January 2018

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Molecular modeling of enzymes and receptors involved in carcinogenesis: QSARs and compact-3D.

21 January 2018

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In vitro methods for assessing human hepatic drug metabolism: their use in drug development

21 January 2018

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Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis

21 January 2018

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Xenobiotic biotransformation/bioactivation in organogenesis-stage conceptual tissues: implications for embryotoxicity and teratogenesis

21 January 2018

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Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.

21 January 2018

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The CYP1A1 gene and cancer susceptibility

21 January 2018

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Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450.

21 January 2018

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Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes.

21 January 2018

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17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Isolation and characterization of the human cytochrome P450 CYP1B1 gene

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Functional analysis of the human cytochrome P4501A1 (CYP1A1) gene enhancer

21 January 2018

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Biochemical individuality and its implications for drug and carcinogen metabolism: recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans

21 January 2018

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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

The use of caffeine as a metabolic probe for human drug metabolizing enzymes

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers—N‐desisopropylation is mediated mainly by CYP1A2

21 January 2018

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Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes

21 January 2018

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Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro

21 January 2018

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Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

21 January 2018

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Metabolism and toxicity of aflatoxins M1 and B1 in human-derived in vitro systems

21 January 2018

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Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

21 January 2018

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Use of heterologously expressed human cytochrome P4501A2 to predict tacrine-fluvoxamine drug interaction in man

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Human Kidney Methoxyflurane and Sevoflurane Metabolism

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Biochemistry and molecular biology of the human CYP2C subfamily

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 isozymes and antiepileptic drug interactions

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Interethnic difference in omeprazole's inhibition of diazepam metabolism*

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Dextromethorphan: polymorphic serum pattern of the O-demethylated and didemethylated metabolites in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetics of dextromethorphan and metabolites in humans: influence of the CYP2D6 phenotype and quinidine inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical enflurane metabolism by cytochrome P450 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical isoflurane metabolism by cytochrome P450 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Area under the plasma concentration-time curve of inorganic fluoride following sevoflurane anesthesia correlates with CYP2E1 mRNA level in mononuclear cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Risk assessment: toxicity from chemical exposure resulting from enhanced expression of CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Induction of cytochrome P450 by toluene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of the chlorofluorocarbon substitute 1,1-dichloro-2,2,2-trifluoroethane by rat and human liver microsomes: the role of cytochrome P450 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The role of cytochrome P450 2E1 in the species-dependent biotransformation of 1,2-dichloro-1,1,2-trifluoroethane in rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Noninvasive tests of CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

21 January 2018

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The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120001392

Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The role of CYP enzymes in cocaine-induced liver damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Midazolam is metabolized by at least three different cytochrome P450 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Interaction between grapefruit juice and midazolam in humans*

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Can grapefruit juice influence ethinylestradiol bioavailability?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The role of lipophilicity in the inhibition of polymorphic cytochrome P450IID6 oxidation by beta-blocking agents in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibitors of imipramine metabolism by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression of human thromboxane synthase using a baculovirus system

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Prostacyclin and thromboxane synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Prostacyclin and Thromboxane Synthase: New Aspects of Hemethiolate Catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Molecular cloning and expression of human prostacyclin synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ascorbic acid prevents cimetidine-induced decrease of serum hydrocortisone concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The effects of cimetidine on the oxidative metabolism of estradiol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Risk of gynaecomastia associated with cimetidine, omeprazole, and other antiulcer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The use of ketoconazole as an inhibitor of steroid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Androgen formation by cytochrome P450 CYP17. Solvent isotope effect and pL studies suggest a role for protons in the regulation of oxene versus peroxide chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P-450 C21scc: one enzyme with two actions: hydroxylase and lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification and characterization of transcriptional regulatory elements of the human aromatase cytochrome P450 gene (CYP19).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of steroid 17 alpha-hydroxylase and C17,20-lyase in the human testis by epitestosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition by omeprazole of adrenocortical response to ACTH: clinical studies and experiments on bovine adrenal cortex in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ketoconazole Blocks Adrenal Steroid Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxylanosterols as modifiers of cholesterol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7 alpha-hydroxydehydroepiandrosterone by human adipose stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Stereoselective inhibition of nortriptyline hydroxylation in man by quinidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of amitriptyline with CYP2D6 expressed in a human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochromes P450 mediating the N-demethylation of amitriptyline

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The inhibition of CYP enzymes in mouse and human liver by pilocarpine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The emerging role of cytochrome P450 3A in psychopharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Substrates of human hepatic cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of nefazodone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Newer antidepressants and the cytochrome P450 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human cytochrome P450 mono-oxygenase system is suppressed by propofol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Macrolide antibacterials. Drug interactions of clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of haloperidol and its tetrahydropyridine dehydration product HPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Saquinavir. Clinical pharmacology and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

A possible role for CYP27 as a major renal mitochondrial 25-hydroxyvitamin D3 1 alpha-hydroxylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetic and pharmacodynamic interactions between diltiazem and quinidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetics and pharmacodynamics in toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The cytochrome P450 4 (CYP4) family

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Induction of the human CYP1A2 enhancer by phorbol ester.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

omega-hydroxylation activity toward leukotriene B(4) and polyunsaturated fatty acids in the human hepatoblastoma cell line, HepG2, and human lung adenocarcinoma cell line, A549.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Dopamine formation from tyramine by CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Modulation of midazolam 1-hydroxylation activity in vitro by neurotransmitters and precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of grapefruit juice on urinary 6 beta-hydroxycortisol/cortisol excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Interaction between grapefruit juice and diazepam in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Induction of drug-metabolizing enzymes by dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Rifampin reduces plasma concentrations and effects of zolpidem.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese: the role of CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of CYP3A inhibition on vesnarinone metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effects of propofol on human hepatic microsomal cytochrome P450 activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Involvement of CYP1A2 in mexiletine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Interactions of amphetamine analogs with human liver CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetics and Metabolism of Bisoprolol Enantiomers in Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Antiprogestin-mediated inactivation of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic interactions of the proton-pump inhibitors lansoprazole, omeprazole and pantoprazole with other drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Single-dose disulfiram does not inhibit CYP2A6 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

HMG-CoA reductase inhibitors and myotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of cerivastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P4501A (CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro assessment of human cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Mechanism-based inactivation of P450 2A6 by furanocoumarins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic interactions of methoxsalen and coumarin in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Toluene metabolism by cDNA-expressed human hepatic cytochrome P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Role of cytochrome P450 enzyme induction in the metabolic activation of benzo[c]phenanthrene in human cell lines and mouse epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of carteolol by cDNA-expressed human cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ipriflavone as an inhibitor of human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of ethyl carbamate by pulmonary cytochrome P450 and carboxylesterase isozymes: involvement of CYP2E1 and hydrolase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Genotoxicity of ethyl carbamate (urethane) in Salmonella, yeast and human lymphoblastoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: absence of binding to the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of human cytochrome P450 1A2 by flavones: a molecular modeling study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human liver microsomal metabolism of paclitaxel and drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human CYP2D6 and metabolism of m-chlorophenylpiperazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Flavonoid inhibition of aromatase enzyme activity in human preadipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of mibefradil

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition selectivity of grapefruit juice components on human cytochromes P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of N,N-dialkylated amphetamines, including deprenyl, by CYP2D6 expressed in a human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinically significant pharmacokinetic drug interactions with carbamazepine. An update

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxidation of nonionic detergents by cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Potent and non-specific inhibition of cytochrome P450 by JM216, a new oral platinum agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P-450 3A4: regulation and role in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Activation of procarcinogens by human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4′-methylene-bis(2-chloroaniline)

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Drug interactions of HIV protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Grapefruit juice substantially increases plasma concentrations of buspirone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Concentrations and effects of buspirone are considerably reduced by rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Determinants of interindividual variability and extent of CYP2D6 and CYP1A2 inhibition by paroxetine and fluvoxamine in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Concentrations and effects of zopiclone are greatly reduced by rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic activation capacity of neonatal mice in relation to the neonatal mouse tumorigenicity bioassay

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Tiagabine: a novel antiepileptic drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Enzymic aromatization of 6-alkyl-substituted androgens, potent competitive and mechanism-based inhibitors of aromatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Selective effects of somatostatin analogs on human drug-metabolizing enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of fibric acid derivatives (fibrates).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibitory monoclonal antibody to human cytochrome P450 2B6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

MR 20492 and MR 20494: two indolizinone derivatives that strongly inhibit human aromatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of rifabutin in human enterocyte and liver microsomes: kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Development of a V79 cell line expressing human cytochrome P450 2D6 and its application as a metabolic screening tool

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N-dechloroethylation of trofosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Grapefruit juice-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 and therapeutic drug monitoring with respect to clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Drug metabolism and atypical antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of multiple products of cytochrome P450 2A6-catalyzed cotinine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

1alpha-Hydroxylase and the action of vitamin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Catalytic properties of polymorphic human cytochrome P450 1B1 variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Resveratrol is a selective human cytochrome P450 1A1 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Review article: cytochrome P450 and the metabolism of proton pump inhibitors--emphasis on rabeprazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Review article: pharmacokinetic concerns in the selection of anti-ulcer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

CYP2A6: a human coumarin 7-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Development of cancer chemopreventive agents: oltipraz as a paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evidence for oxidative metabolism in the genotoxicity of the atmospheric reaction product 2-nitronaphthalene in human lymphoblastoid cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Formation of indigo by recombinant mammalian cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Variable contribution of CYP2D6 to the N-dealkylation of S-(-)-propranolol by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Activation of the Ah receptor by tryptophan and tryptophan metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetics of haloperidol: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of troglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Olanzapine. Pharmacokinetic and pharmacodynamic profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Molecular mechanisms of the effects of sildenafil (VIAGRA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of mirtazapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

CYP2D6 inhibition by fluoxetine, paroxetine, sertraline, and venlafaxine in a crossover study: intraindividual variability and plasma concentration correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Contribution of cholesterol 7alpha-hydroxylase to the regulation of lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Mutagenicity of C24H14 PAH in human cells expressing CYP1A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Azalanstat (RS-21607), a lanosterol 14α-demethylase inhibitor with cholesterol-lowering activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Sulphonation of N-hydroxy-2-acetylaminofluorene by human dehydroepiandrosterone sulphotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism-based drug interactions involving oral azole antifungals in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacokinetics of selective serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics of clarithromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The role of CYP2B6 in human xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of highly persistent PCB congener, 2,4,5,2',4',5'-hexachlorobiphenyl, by human CYP2B6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochrome P-450 inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: the role of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Mefloquine metabolism by human liver microsomes. Effect of other antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Primaquine metabolism by human liver microsomes: effect of other antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 species involved in the metabolism of quinoline

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Involvement of CYP3A4 in the metabolism of bromperidol in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of drug-metabolizing enzyme activity in human hepatic cytochrome P450s by bisphenol A

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 2C is an EDHF synthase in coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Pharmacologic, pharmacokinetic, and therapeutic differences among angiotensin II receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of diet and nutrition on the expression of cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Fluvoxamine but not citalopram increases serum melatonin in healthy subjects-- an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Induction of cytochrome P-450 1A1 in human hepatoma HepG2 and lung carcinoma NCI-H322 cells by motorcycle exhaust particulate

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Diflubenzuron, a benzoyl-urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Biotransformation of Post-Clozapine Antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Conversion of pregnenolone to DHEA by human 17alpha-hydroxylase/17, 20-lyase (P450c17). Evidence that DHEA is produced from the released intermediate, 17alpha-hydroxypregnenolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolic conversion of methoxymorpholinyl doxorubicin: from a DNA strand breaker to a DNA cross-linker

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of enzymes responsible for rifalazil metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Role of cytochrome P4501A1 in biotransformation of a tissue specific sarcomagen N-methyldibenzo[c,g]carbazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Enzyme induction and inhibition by new antiepileptic drugs: a review of human studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Selection of 19-(ethyldithio)-androst-4-ene-3,17-dione (ORG 30958): A potent aromatase inhibitor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Thoughts on carcinogenesis testing: the FDA today

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxidation of indole by cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Grapefruit juice can increase the plasma concentrations of oral methylprednisolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1'-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The xenobiotic inhibitor profile of cytochrome P4502C8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

2,2',4,6,6'-pentachlorobiphenyl induces apoptosis in human monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Lymphocyte P-glycoprotein expression and activity before and after rifampicin in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz(a)anthracene in astrocytoma cell line (MOG-G-CCM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of trichloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

What makes P450s work? Searches for answers with known and new P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Arachidonic acid-mediated cooxidation of all-trans-retinoic acid in microsomal fractions from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

In vitro identification of the cytochrome P450 isoform responsible for the metabolism of alpha-dihydroergocryptine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Identification of the human and animal hepatic cytochromes P450 involved in clonazepam metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of 26,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 26,27-hexafluoro-1 alpha,23(S)25-trihydroxyvitamin D3 in ROS17/2.8 cells transfected with a plasmid expressing CYP24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

cDna cloning and expression of CYP4F12, a novel human cytochrome P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Selective inhibition of vitamin D hydroxylases in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of the beta-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-beta-hydroxypropylpropylamine and N-nitroso-beta-oxopropylpropylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

P450 interaction with HIV protease inhibitors: relationship between metabolic stability, inhibitory potency, and P450 binding spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Formation of a defluorinated metabolite of a quinoxaline antiviral drug catalysed by human cytochrome P450 1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Comparative studies on coumarin and testosterone metabolism in mouse and human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Oxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Comparison of the Substrate Specificities of Human Liver Cytochrome P450s 2C9 and 2C18: Application to the Design of a Specific Substrate of CYP 2C18

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Cytochrome P450 isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of NS-21

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Selectivity of Polycyclic Inhibitors for Human Cytochrome P450s 1A1, 1A2, and 1B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Phospholipase D Activity of Cytochrome P450 in Human Liver Endoplasmic Reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activityin vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus)

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120001392

21 January 2018

Identifiers

DOI

10.1081/DMR-120001392

1 reference

6 July 2017

1 reference