Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli (Q36071390)

12 August 2017

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli (English)

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12 August 2017

10

Chris Cotsapas

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12 August 2017

11

David A Hafler

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12 August 2017

5

Jaime Grutzendler

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12 August 2017

William J Housley

1

1 reference

12 August 2017

Salvador D Fernandez

2

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12 August 2017

Kenneth Vera

3

1 reference

12 August 2017

Sasidhar R Murikinati

4

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12 August 2017

Nicole Cuerdon

6

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12 August 2017

Laura Glick

7

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12 August 2017

Phillip L De Jager

8

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12 August 2017

Mitja Mitrovic

9

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12 August 2017

language of work or name

English

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publication date

1 June 2015

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Science Translational Medicine

12 August 2017

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12 August 2017

7

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12 August 2017

291

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12 August 2017

291ra93

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4574294/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Variation in the human immune system is largely driven by non-heritable influences

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Genetic and epigenetic fine mapping of causal autoimmune disease variants

2 October 2017

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Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

2 October 2017

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Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients

2 October 2017

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Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus

2 October 2017

1 reference

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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

2 October 2017

1 reference

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Immunogenicity and autoimmunity during anti-TNF therapy.

2 October 2017

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An integrated map of genetic variation from 1,092 human genomes

2 October 2017

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Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity

2 October 2017

1 reference

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Immune-mediated disease genetics: the shared basis of pathogenesis

2 October 2017

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Systematic localization of common disease-associated variation in regulatory DNA

2 October 2017

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The accessible chromatin landscape of the human genome

2 October 2017

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An integrated encyclopedia of DNA elements in the human genome

2 October 2017

1 reference

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TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

2 October 2017

1 reference

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NF-κB, the first quarter-century: remarkable progress and outstanding questions

2 October 2017

1 reference

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Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

2 October 2017

1 reference

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Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

2 October 2017

1 reference

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Pervasive sharing of genetic effects in autoimmune disease

2 October 2017

1 reference

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The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation

2 October 2017

1 reference

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

2 October 2017

1 reference

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IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis

2 October 2017

1 reference

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Regulation of NF-κB induction by TCR/CD28.

2 October 2017

1 reference

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Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease

2 October 2017

1 reference

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Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

2 October 2017

1 reference

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Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

2 October 2017

1 reference

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Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

2 October 2017

1 reference

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Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease.

2 October 2017

1 reference

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TNF receptor 2 pathway: drug target for autoimmune diseases

2 October 2017

1 reference

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The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions

2 October 2017

1 reference

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NF-kappaB dimers in the regulation of neuronal survival.

2 October 2017

1 reference

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What controls nucleosome positions?

2 October 2017

1 reference

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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Allelic variant in CTLA4 alters T cell phosphorylation patterns

2 October 2017

1 reference

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PLINK: a tool set for whole-genome association and population-based linkage analyses

2 October 2017

1 reference

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Mapping of transcription factor binding regions in mammalian cells by ChIP: comparison of array- and sequencing-based technologies

2 October 2017

1 reference

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Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

2 October 2017

1 reference

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High-throughput methods of regulatory element discovery

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

A multiple sclerosis-associated variant of CBLB links genetic risk with type I IFN function.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

Increased CXCL8 (IL-8) expression in Multiple Sclerosis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574294

23 September 2018

1 reference

12 December 2020

IP-10 and MCP-1 levels in CSF and serum from multiple sclerosis patients with different clinical subtypes of the disease

1 reference

12 December 2020

Profile of cerebrospinal fluid and serum cytokines in patients with relapsing-remitting multiple sclerosis: a correlation with clinical activity

1 reference

12 December 2020

The levels of chemokines CXCL8, CCL2 and CCL5 in multiple sclerosis patients are linked to the activity of the disease

1 reference

12 December 2020

Failure of anti-TNF therapy in TNF Receptor 1-Associated Periodic Syndrome (TRAPS)

1 reference

12 December 2020

Systems biology for identification of molecular networks in multiple sclerosis

1 reference

12 December 2020

10.1126/SCITRANSLMED.AAA9223

Identifiers

DOI

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

26062845

1 reference