Genetic and epigenetic fine mapping of causal autoimmune disease variants (Q28649603)

Markus Kleinewietfeld

4

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Nikolaos A. Patsopoulos

Nikolaos A Patsopoulos

15

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Mark Joseph Daly

19

Mark J Daly

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David A. Hafler

20

David A Hafler

0 references

Philip L. De Jager

16

Philip L De Jager

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Vijay Kuchroo

17

Vijay K Kuchroo

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Bradley Bernstein

21

Bradley E Bernstein

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author name string

Kyle Kai-How Farh

1

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Alexander Marson

2

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Jiang Zhu

3

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William J Housley

5

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Samantha Beik

6

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Noam Shoresh

7

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Holly Whitton

8

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Russell J H Ryan

9

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Alexander A Shishkin

10

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Meital Hatan

11

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Marlene J Carrasco-Alfonso

12

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Dita Mayer

13

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C John Luckey

14

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Charles B Epstein

Super-enhancers in the control of cell identity and disease

18

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language of work or name

English

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publication date

19 February 2015

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published in

Nature

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volume

518

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page(s)

337-43

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issue

7539

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cites work

1 reference

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A validated regulatory network for Th17 cell specification

17 March 2017

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17 March 2017

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

17 March 2017

1 reference

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Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

17 March 2017

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TGF-beta: a master of all T cell trades

17 March 2017

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Foxp3 occupancy and regulation of key target genes during T-cell stimulation

17 March 2017

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Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

17 March 2017

1 reference

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DNA-binding specificities of human transcription factors

17 March 2017

1 reference

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Mapping and analysis of chromatin state dynamics in nine human cell types

17 March 2017

1 reference

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Systematic localization of common disease-associated variation in regulatory DNA

7 April 2017

1 reference

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Genetic mapping in human disease

7 April 2017

1 reference

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The NIH Roadmap Epigenomics Mapping Consortium

7 April 2017

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Heritability and genomics of gene expression in peripheral blood

7 April 2017

1 reference

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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

3 June 2018

1 reference

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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Effect of natural genetic variation on enhancer selection and function.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

3 June 2018

Mapping human epigenomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Genetic insights into common pathways and complex relationships among immune-mediated diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Transcriptional and epigenetic dynamics during specification of human embryonic stem cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Genome-wide chromatin state transitions associated with developmental and environmental cues

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Chromatin marks identify critical cell types for fine mapping complex trait variants

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Expanding roles for GILT in immunity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

STATs shape the active enhancer landscape of T cell populations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Bayesian refinement of association signals for 14 loci in 3 common diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

High-resolution transcriptome of human macrophages

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Architecture of the human regulatory network derived from ENCODE data

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Seven newly identified loci for autoimmune thyroid disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Fast gapped-read alignment with Bowtie 2

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Functional and mechanistic diversity of distal transcription enhancers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Plasticity of CD4+ T cell lineage differentiation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Fast and accurate short read alignment with Burrows-Wheeler transform

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

B cells move to centre stage: novel opportunities for autoimmune disease treatment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Genetic analysis of autoimmune disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4336207

Latent enhancers activated by stimulation in differentiated cells

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE13835

CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE13835

Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25363779

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isolation of mononuclear cells from tonsillar tissue

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25363779

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tests for Linear Trends in Proportions and Frequencies

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE13835

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE13835

1 reference

Dimensions Publication ID

43014

1021809129

0 references

43014

1 reference

1 reference

1 reference