TNF receptor 2 pathway: drug target for autoimmune diseases (Q37758202)

22 August 2017

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title

TNF receptor 2 pathway: drug target for autoimmune diseases (English)

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22 August 2017

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Denise Faustman

1

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PubMed ID

20489699

22 August 2017

Miriam Davis

series ordinal

2

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22 August 2017

21 May 2010

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Nature Reviews Drug Discovery

22 August 2017

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22 August 2017

9

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22 August 2017

482-493

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22 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrd3030

22 August 2017

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Psoriatic lesions induced by antitumour necrosis factor-alpha treatment: two cases

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Dermatological conditions during TNF-alpha-blocking therapy in patients with rheumatoid arthritis: a prospective study

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Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: a prospective cohort study.

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Development of type 1 diabetes in a patient treated with anti-TNF-alpha therapy for active rheumatoid arthritis

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The Pittsburgh insulin-dependent diabetes mellitus (IDDM) morbidity and mortality study. Mortality results.

31 March 2020

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Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex

31 March 2020

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Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant

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Signalling pathways of the TNF superfamily: a double-edged sword

31 March 2020

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Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

31 March 2020

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The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis

31 March 2020

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The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

31 March 2020

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NOD2 and Crohn's disease: loss or gain of function?

31 March 2020

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

31 March 2020

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

31 March 2020

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TNF promoter polymorphisms and modulation of growth retardation and disease severity in pediatric Crohn's disease

31 March 2020

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Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors

31 March 2020

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Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis

31 March 2020

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Abnormal T lymphocyte signal transduction in systemic lupus erythematosus

31 March 2020

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NFkappaB polymorphisms and susceptibility to type 1 diabetes

31 March 2020

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Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes

31 March 2020

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Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis

31 March 2020

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NOD mice are defective in proteasome production and activation of NF-kappaB

31 March 2020

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Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis

31 March 2020

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Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations

31 March 2020

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Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

31 March 2020

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The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies

31 March 2020

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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

31 March 2020

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Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

31 March 2020

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Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice.

31 March 2020

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Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes

31 March 2020

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Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice

31 March 2020

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Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells

31 March 2020

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Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant

31 March 2020

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Reversal of established autoimmune diabetes by restoration of endogenous beta cell function

31 March 2020

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Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution

31 March 2020

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Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.

31 March 2020

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Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration

31 March 2020

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Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice

31 March 2020

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Tumor necrosis factor activities and cancer therapy--a perspective

31 March 2020

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Tumor necrosis factor for the treatment of malignancies

31 March 2020

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Tumour necrosis factor and cancer

31 March 2020

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In vivo apoptosis of diabetogenic T cells in NOD mice by IFN-gamma/TNF-alpha

31 March 2020

1 reference

A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis

31 March 2020

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Reversal of Sjogren's-like syndrome in non-obese diabetic mice

31 March 2020

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Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

31 March 2020

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Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation.

31 March 2020

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Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice.

31 March 2020

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

31 March 2020

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Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways.

31 March 2020

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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

31 March 2020

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TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination.

31 March 2020

1 reference

Expression of the p75 TNF receptor is linked to TNF-induced NFkappaB translocation and oxyradical neutralization in glial cells

31 March 2020

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Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium

31 March 2020

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The two different receptors for tumor necrosis factor mediate distinct cellular responses

31 March 2020

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Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

31 March 2020

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IKK-2 is required for TNF-alpha-induced invasion and proliferation of human mesenchymal stem cells

31 March 2020

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Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells

31 March 2020

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Function and regulation of tumor necrosis factor receptor type 2.

31 March 2020

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A novel domain within the 55 kd TNF receptor signals cell death

31 March 2020

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

31 March 2020

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Death receptor signal transducers: nodes of coordination in immune signaling networks

31 March 2020

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

31 March 2020

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

31 March 2020

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Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.

31 March 2020

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TNF receptor superfamily-induced cell death: redox-dependent execution

31 March 2020

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Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells

31 March 2020

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Circuitry of nuclear factor kappaB signaling

31 March 2020

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Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences

31 March 2020

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The RIP kinases: crucial integrators of cellular stress

31 March 2020

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Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF.

31 March 2020

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Induction of apoptosis in mature T cells by tumour necrosis factor

31 March 2020

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The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

31 March 2020

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Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor I-dependent mechanism.

31 March 2020

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Control of receptor-induced signaling complex formation by the kinetics of ligand/receptor interaction.

31 March 2020

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TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

31 March 2020

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Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site

31 March 2020

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

31 March 2020

1 reference

Mechanisms of sex differences in TNFR2-mediated cardioprotection

31 March 2020

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Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitis

31 March 2020

1 reference

Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pat

31 March 2020

1 reference

Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction

31 March 2020

1 reference

Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians

31 March 2020

2 references

31 March 2020

12 December 2020

Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneity.

1 reference

Study of functional variants of theBANK1gene in rheumatoid arthritis

31 March 2020

1 reference

Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively

31 March 2020

1 reference

Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus

31 March 2020

1 reference

Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab

31 March 2020

1 reference

Polymorphisms in TNFA and TNFR2 affect outcome of unrelated bone marrow transplantation

31 March 2020

1 reference

The Met-196 -> Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression

31 March 2020

1 reference

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study

31 March 2020

1 reference

Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis.

31 March 2020

1 reference

Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans

31 March 2020

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Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-alpha antibody.

31 March 2020

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Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

31 March 2020

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Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo

31 March 2020

1 reference

Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases

31 March 2020

1 reference

Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse

31 March 2020

1 reference

Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders

31 March 2020

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Reply to 'LMP2 expression and proteasome activity in NOD mice'

31 March 2020

1 reference

Increased CD8+ T cell apoptosis in scleroderma is associated with low levels of NF-kappa B.

31 March 2020

1 reference

A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon

31 March 2020

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Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.

31 March 2020

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TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function.

31 March 2020

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Mechanisms of T regulatory cell function

31 March 2020

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A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.

31 March 2020

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PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination

31 March 2020

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Small-molecule inhibition of TNF-alpha

31 March 2020

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Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75

31 March 2020

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Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer

31 March 2020

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C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L.

31 March 2020

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

31 March 2020

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

31 March 2020

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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

31 March 2020

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Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years

31 March 2020

1 reference

Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3gamma1 (Ala-Ala).

31 March 2020

1 reference

An endotoxin-induced serum factor that causes necrosis of tumors

31 March 2020

1 reference

AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2.

31 March 2020

1 reference

Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case series.

31 March 2020

1 reference

12 December 2020

Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site

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12 December 2020

TNF signaling: early events and phosphorylation.

1 reference

12 December 2020

TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60

1 reference

12 December 2020

Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.

1 reference

12 December 2020

Leukocytoclastic vasculitis due to etanercept

1 reference

12 December 2020

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

1 reference

12 December 2020

Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

1 reference

12 December 2020

Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene

1 reference

12 December 2020

Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation

1 reference

12 December 2020

The role of tumor necrosis factor (TNF)-alpha and TNF receptor polymorphisms in susceptibility to ankylosing spondylitis.

1 reference

12 December 2020

Circulating levels of tumor necrosis factor soluble receptors in systemic lupus erythematosus are significantly higher than in other rheumatic diseases and correlate with disease activity

1 reference

12 December 2020

Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells

1 reference

12 December 2020

Pustular psoriasis induced by infliximab

1 reference

12 December 2020

Inhibition of p75 tumor necrosis factor receptor by antisense oligonucleotides increases hypoxic injury and beta-amyloid toxicity in human neuronal cell line

1 reference

12 December 2020

Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter.

1 reference

12 December 2020

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity

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12 December 2020

Identifiers

DOI

10.1038/NRD3030

1 reference

PubMed ID

20489699

Dimensions Publication ID

22 August 2017

0 references

1 reference

PubMed ID

20489699