Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes (Q36078791)

12 August 2017

Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes (English)

1 reference

12 August 2017

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7

Quan Chen

1 reference

12 August 2017

Xiaohu Huang

2

0 references

Hongqiang Cheng

object named as

Hongqiang Cheng

5

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author name string

Ting Zhao

1

1 reference

12 August 2017

Liang Han

3

1 reference

12 August 2017

Xianhua Wang

4

1 reference

12 August 2017

Yungang Zhao

6

1 reference

12 August 2017

Ju Chen

8

1 reference

12 August 2017

Heping Cheng

9

1 reference

12 August 2017

Ruiping Xiao

10

1 reference

12 August 2017

Ming Zheng

11

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12 August 2017

language of work or name

English

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publication date

22 May 2012

1 reference

Journal of Biological Chemistry

12 August 2017

1 reference

12 August 2017

287

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12 August 2017

28

1 reference

12 August 2017

23615-23625

1 reference

describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3390636/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

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Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes

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Role of mitofusin 2 in cardiovascular oxidative injury

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Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair

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Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

2 October 2017

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FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport

2 October 2017

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A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

2 October 2017

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

2 October 2017

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

2 October 2017

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Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.

2 October 2017

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

2 October 2017

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High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

2 October 2017

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Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations

2 October 2017

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

2 October 2017

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2 October 2017

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Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis

2 October 2017

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Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations

2 October 2017

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Mitochondria: dynamic organelles in disease, aging, and development

2 October 2017

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Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

2 October 2017

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

2 October 2017

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2 October 2017

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OPA1 requires mitofusin 1 to promote mitochondrial fusion

2 October 2017

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Role for Rab7 in maturation of late autophagic vacuoles

2 October 2017

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Dysregulation of HSG triggers vascular proliferative disorders

2 October 2017

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Structural basis of mitochondrial tethering by mitofusin complexes.

2 October 2017

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Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

2 October 2017

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Dynamics of mitochondrial morphology in healthy cells and during apoptosis

2 October 2017

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Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells

2 October 2017

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Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity

2 October 2017

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

2 October 2017

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Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo

2 October 2017

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Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology

2 October 2017

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2 October 2017

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Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

2 October 2017

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The machinery of mitochondrial inheritance and behavior

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390636

Mitochondrial diseases in man and mouse

2 October 2017

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Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

2 October 2017

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Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle

2 October 2017

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Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice

2 October 2017

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Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway

23 September 2018

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Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390636

Three-dimensional mitochondrial arrangement in ventricular myocytes: from chaos to order.

23 September 2018

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The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390636

Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390636

Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390636

Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390636

A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiac growth or hypertrophy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390636

Not All Autophagy Membranes Are Created Equal

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.379164

Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22619176

12 December 2020

inferred from PubMed ID database lookup

Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22619176

12 December 2020

inferred from PubMed ID database lookup

Multiple deletions are detectable in mitochondrial DNA of aging mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22619176

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M112.379164

1 reference

12 August 2017

1 reference

12 August 2017

1 reference