Polo-like Kinase&#160;1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma (Q36107521)

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21 March 2020

title

Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma (English)

1 reference

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21 March 2020

main subject

diffuse midline glioma

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author

Nicholas K Foreman

10

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21 March 2020

Rajeev Vibhakar

12

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21 March 2020

6

Andrew M Donson

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21 March 2020

author name string

Vladimir Amani

1

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21 March 2020

Eric W Prince

2

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21 March 2020

Irina Alimova

3

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21 March 2020

Ilango Balakrishnan

4

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21 March 2020

Diane Birks

5

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21 March 2020

Peter Harris

7

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21 March 2020

Jean M Mulcahy Levy

8

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21 March 2020

Michael Handler

9

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21 March 2020

Sujatha Venkataraman

11

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21 March 2020

language of work or name

English

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publication date

18 August 2016

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21 March 2020

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21 March 2020

volume

16

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21 March 2020

page(s)

647

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Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma

21 March 2020

cites work

1 reference

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Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma

2 October 2017

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Histone H3.3 maintains genome integrity during mammalian development

2 October 2017

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A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

2 October 2017

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Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

2 October 2017

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A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies.

2 October 2017

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Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

2 October 2017

1 reference

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Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

2 October 2017

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The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

2 October 2017

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Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children

2 October 2017

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Diffuse intrinsic pontine glioma: poised for progress

2 October 2017

1 reference

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Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma

2 October 2017

1 reference

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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

2 October 2017

1 reference

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Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

2 October 2017

1 reference

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Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma

2 October 2017

1 reference

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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

2 October 2017

1 reference

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Targeting Polo-like kinase in cancer therapy

2 October 2017

1 reference

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Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas

2 October 2017

1 reference

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BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

2 October 2017

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Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis.

2 October 2017

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Targeting cell cycle kinases for cancer therapy

2 October 2017

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Diffuse brainstem glioma in children: critical review of clinical trials

2 October 2017

1 reference

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Normal cells, but not cancer cells, survive severe Plk1 depletion

2 October 2017

1 reference

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Regulation of cell cycle checkpoints by polo-like kinases

2 October 2017

1 reference

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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

2 October 2017

1 reference

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Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

2 October 2017

1 reference

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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

Phase I dose escalation and pharmacokinetic study of BI 2536, a novel Polo-like kinase 1 inhibitor, in patients with advanced solid tumors.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

Targeting polo-like kinase 1 for cancer therapy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4991074

10.1186/S12885-016-2690-6

23 September 2018

Identifiers

DOI

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Dimensions Publication ID

21 March 2020

0 references

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21 March 2020

PubMed publication ID

27538997

1 reference