Ubiquitin chains in the ladder of MAPK signaling (Q36108376)

12 August 2017

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title

Ubiquitin chains in the ladder of MAPK signaling (English)

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12 August 2017

2

Ze'ev Ronai

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author name string

Aaron Laine

series ordinal

1

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12 August 2017

26 April 2005

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Science's STKE : signal transduction knowledge environment

12 August 2017

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12 August 2017

2005

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12 August 2017

281

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12 August 2017

re5

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

12 August 2017

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

In vitro assembly and recognition of Lys-63 polyubiquitin chains

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Membrane localization of TRAF 3 enables JNK activation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

NF-kappaB signaling: flipping the switch with polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The novel functions of ubiquitination in signaling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Negative regulation of JNK signaling by the tumor suppressor CYLD.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Stress-induced decrease in TRAF2 stability is mediated by Siah2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Regulation of TRAF2 signaling by self-induced degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Noncatalytic requirement for cyclin A-cdk2 in p27 turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

IKKalpha controls formation of the epidermis independently of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

A cytoplasmic inhibitor of the JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

A mammalian scaffold complex that selectively mediates MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The Drosophila F box protein archipelago regulates dMyc protein levels in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Covalent modification of PML by the sentrin family of ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

ERK7 is an autoactivated member of the MAPK family

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2812005RE5

21 January 2018

Identifiers

DOI

10.1126/STKE.2812005RE5

1 reference

12 August 2017

1 reference

PubMed ID

15855411