The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy (Q36118105)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26365381%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26365381%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

2

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24 February 2020

Jeffrey W. Harper

5

1 reference

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24 February 2020

author name string

Jin-Mi Heo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26365381%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Joao A Paulo

3

1 reference

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24 February 2020

Jesse Rinehart

4

1 reference

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24 February 2020

publication date

10 September 2015

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24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26365381%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

60

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24 February 2020

page(s)

7-20

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24 February 2020

issue

1

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A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation

24 February 2020

cites work

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Quantifying ubiquitin signaling

2 October 2017

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TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

2 October 2017

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Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.

2 October 2017

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

2 October 2017

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Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation

2 October 2017

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

2 October 2017

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USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

2 October 2017

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2 October 2017

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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

2 October 2017

1 reference

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Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

2 October 2017

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Cargo recognition and trafficking in selective autophagy

2 October 2017

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Ubiquitin is phosphorylated by PINK1 to activate parkin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4592482

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

2 October 2017

1 reference

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

2 October 2017

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Genome engineering using the CRISPR-Cas9 system

2 October 2017

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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

2 October 2017

1 reference

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LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

2 October 2017

1 reference

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

2 October 2017

1 reference

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Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4592482

Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

2 October 2017

1 reference

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TBK1 mediates crosstalk between the innate immune response and autophagy

2 October 2017

1 reference

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Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

2 October 2017

1 reference

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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

2 October 2017

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Novel cross-talk within the IKK family controls innate immunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4592482

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4592482

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

2 October 2017

1 reference

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Mutations of optineurin in amyotrophic lateral sclerosis

2 October 2017

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The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

2 October 2017

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NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

2 October 2017

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Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

2 October 2017

1 reference

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

2 October 2017

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Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

2 October 2017

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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

2 October 2017

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

2 October 2017

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IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2

2 October 2017

1 reference

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Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells

2 October 2017

1 reference

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SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

2 July 2018

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Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

23 September 2018

1 reference

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Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4592482

Analysis of OPTN as a causative gene for amyotrophic lateral sclerosis

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26365381

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2015.08.016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26365381%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26365381%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26365381%20AND%20SRC:MED&resulttype=core&format=json