TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation (Q38875214)

7 September 2017

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation (English)

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7 September 2017

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3

Nobutaka Hattori

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7 September 2017

Gen Matsumoto

1

1 reference

PubMed ID

25972374

7 September 2017

Tomomi Shimogori

series ordinal

2

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PubMed ID

25972374

7 September 2017

Nobuyuki Nukina

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4

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7 September 2017

13 May 2015

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7 September 2017

Human Molecular Genetics

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7 September 2017

24

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7 September 2017

4429-4442

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7 September 2017

15

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Autophagy: renovation of cells and tissues

7 September 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

The LIR motif - crucial for selective autophagy

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Selective autophagy mediated by autophagic adapter proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Solution Structure of the Ubiquitin-associated (UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

A role for ubiquitin in selective autophagy

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Negative regulation of TBK1-mediated antiviral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Neurodegeneration as a consequence of failed mitochondrial maintenance

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Regulation of autophagy by ROS: physiology and pathology

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Parkin and PINK1: much more than mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

21 January 2018

Regulation by mitophagy

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

21 January 2018

Mechanisms of mitophagy

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Crystal structure and mechanism of activation of TANK-binding kinase 1

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

NAK is an IkappaB kinase-activating kinase

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Functional dissection of the TBK1 molecular network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Toward an integrative view of Optineurin functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: the emerging role of cellular localization in the activation and substrate specificity of TBK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV179

21 January 2018

Identifiers

DOI

10.1093/HMG/DDV179

1 reference

7 September 2017

1 reference

PubMed ID

25972374