Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice (Q36145724)

12 August 2017

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice (English)

1 reference

12 August 2017

9

Shan Zha

1 reference

12 August 2017

Kenta Yamamoto

1

1 reference

12 August 2017

Yunyue Wang

2

1 reference

12 August 2017

Wenxia Jiang

3

1 reference

12 August 2017

Xiangyu Liu

4

1 reference

12 August 2017

Richard L Dubois

5

1 reference

12 August 2017

Chyuan-Sheng Lin

6

1 reference

12 August 2017

Thomas Ludwig

7

1 reference

12 August 2017

Christopher J Bakkenist

8

1 reference

12 August 2017

language of work or name

English

0 references

publication date

1 August 2012

1 reference

12 August 2017

9

1 reference

based on heuristic

inferred from page(s)

published in

Journal of Cell Biology

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12 August 2017

198

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12 August 2017

3

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12 August 2017

305-313

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Loss of ATM kinase activity leads to embryonic lethality in mice

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

ATR autophosphorylation as a molecular switch for checkpoint activation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

ATM protein kinase: the linchpin of cellular defenses to stress

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

A bright and photostable photoconvertible fluorescent protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Complementary functions of ATM and H2AX in development and suppression of genomic instability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

ATM is required for efficient recombination between immunoglobulin switch regions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

The role of the non-homologous end-joining pathway in lymphocyte development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

The Mre11 complex is required for ATM activation and the G2/M checkpoint

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Requirement of the MRN complex for ATM activation by DNA damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

A murine model of Nijmegen breakage syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Atm-deficient mice: a paradigm of ataxia telangiectasia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Analysis of the ATM protein in wild-type and ataxia telangiectasia cells

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413350

Modeling ATM mutant proteins from missense changes confirms retained kinase activity.

2 July 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201204098

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201204098

Predominance of null mutations in ataxia-telangiectasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201204098

Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201204098

Dual roles of ATM in the cellular response to radiation and in cell growth control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201204098

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201204098

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22869596

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201204098

1 reference

release_gtckc6nngnhatktonoano2o3di

12 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gtckc6nngnhatktonoano2o3di

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

12 August 2017

1 reference