Proteolytic mechanisms in necrotic cell death and neurodegeneration (Q36156010)

12 August 2017

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title

Proteolytic mechanisms in necrotic cell death and neurodegeneration (English)

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12 August 2017

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Nektarios Tavernarakis

series ordinal

2

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12 August 2017

Marta Artal-Sanz

1

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language of work or name

English

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publication date

2 April 2005

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12 August 2017

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12 August 2017

579

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12 August 2017

15

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12 August 2017

3287-3296

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Diversity in the mechanisms of neuronal cell death.

12 August 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Adult neuron survival strategies--slamming on the brakes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Neuronal cell death: a demise with different shapes.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Apoptosis in neurodegenerative disorders

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Role of apoptotic proteins in ischemic hippocampal damage.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Apoptosis after experimental stroke: fact or fashion?

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

An alternative, nonapoptotic form of programmed cell death

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

21 January 2018

More than one way to go.

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Cell death: critical control points

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Apoptosis: corralling the corpses

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

The biochemistry of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Four deaths and a funeral: from caspases to alternative mechanisms.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Molecular basis of the neurodegenerative disorders

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Toxic proteins in neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

21 January 2018

Excitotoxic cell death

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Excitotoxic versus apoptotic mechanisms of neuronal cell death in perinatal hypoxia/ischemia

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

A key role for TRPM7 channels in anoxic neuronal death

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Epithelial sodium channel related to proteins involved in neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Molecular mechanisms of calcium-dependent excitotoxicity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Microglial functions and proteases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

The aggravating role of the ubiquitin-proteasome system in neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Mechanisms of caspase activation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain and caspase: can you tell the difference?

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Disruption of the mouse mu-calpain gene reveals an essential role in platelet function

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Neurotoxicity induces cleavage of p35 to p25 by calpain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Huntingtin is degraded to small fragments by calpain after ischemic injury.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpains mediate p53 activation and neuronal death evoked by DNA damage.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain and mitochondria in ischemia/reperfusion injury

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain-dependent neurofilament breakdown in anoxic and ischemic rat central axons.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Phosphoinositide 3-kinase accelerates calpain-dependent proteolysis of fodrin during hypoxic cell death

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Myosin Va is proteolysed in rat cerebellar granule neurons after excitotoxic injury

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Organelle-specific initiation of cell death pathways

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Neuronal and microglial cathepsins in aging and age-related diseases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Drosophila long-term memory formation involves regulation of cathepsin activity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Gene deletion of cystatin C aggravates brain damage following focal ischemia but mitigates the neuronal injury after global ischemia in the mouse.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Identification of Cathepsin B as a Mediator of Neuronal Death Induced by Aβ-activated Microglial Cells Using a Functional Genomics Approach

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

The genetic association between Cathepsin D and Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Cutting to the chase: calpain proteases in cell motility

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Molecular cloning and analysis of small optic lobes, a structural brain gene of Drosophila melanogaster

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Calpain activation is upstream of caspases in radiation-induced apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.03.052

10.1016/J.FEBSLET.2005.03.052

21 January 2018

Identifiers

DOI

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12 August 2017

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PubMed ID

15943973