Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. (Q36174127)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22897851%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia (English)

1 reference

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11 February 2020

1 reference

6

1 reference

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Richard A. Young

13

1 reference

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1

Takaomi Sanda

1 reference

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A Thomas Look

1 reference

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author name string

Lee N Lawton

2

1 reference

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11 February 2020

M Inmaculada Barrasa

3

1 reference

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11 February 2020

Zi Peng Fan

4

1 reference

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11 February 2020

Holger Kohlhammer

5

1 reference

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11 February 2020

Wenxue Ma

7

1 reference

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11 February 2020

Jessica Tatarek

8

1 reference

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11 February 2020

Yebin Ahn

9

1 reference

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11 February 2020

Michelle A Kelliher

10

1 reference

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11 February 2020

Catriona H M Jamieson

11

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11 February 2020

Louis M Staudt

12

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11 February 2020

publication date

1 August 2012

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11 February 2020

1 reference

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11 February 2020

volume

22

1 reference

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11 February 2020

issue

2

1 reference

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11 February 2020

page(s)

209-221

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Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

11 February 2020

cites work

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

1 October 2017

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1 October 2017

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1 October 2017

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Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

1 October 2017

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1 October 2017

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1 October 2017

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ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

1 October 2017

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1 October 2017

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An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene

1 October 2017

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Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation

1 October 2017

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Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

1 October 2017

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cis-Regulatory remodeling of the SCL locus during vertebrate evolution.

1 October 2017

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Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

1 October 2017

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NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

1 October 2017

1 reference

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Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

1 October 2017

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A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

1 October 2017

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

1 October 2017

1 reference

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The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

1 October 2017

1 reference

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DNA specificity determinants associate with distinct transcription factor functions

1 October 2017

1 reference

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The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.

1 October 2017

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E and ID proteins branch out.

1 October 2017

1 reference

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Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

RUNX proteins in transcription factor networks that regulate T-cell lineage choice

1 October 2017

1 reference

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Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data

1 October 2017

1 reference

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GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation

1 October 2017

1 reference

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Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

1 October 2017

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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells

1 October 2017

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MYB function in normal and cancer cells

1 October 2017

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Alu elements mediate MYB gene tandem duplication in human T-ALL

1 October 2017

1 reference

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Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer

1 October 2017

1 reference

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Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.

1 October 2017

1 reference

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Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

1 October 2017

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Network motifs: theory and experimental approaches

1 October 2017

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Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

1 October 2017

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Chromatin immunoprecipitation and microarray-based analysis of protein location

1 October 2017

1 reference

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Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

A loss-of-function RNA interference screen for molecular targets in cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Molecular genetics of acute lymphoblastic leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Identification of a TAL1 Target Gene Reveals a Positive Role for the LIM Domain-Binding Protein Ldb1 in Erythroid Gene Expression and Differentiation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Helix-loop-helix (E2-5, HEB, TAL1 and Id1) protein interaction with the TCRalphadelta enhancers

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Densely interconnected transcriptional circuits control cell states in human hematopoiesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Oncogenic transcription factors in the human acute leukemias

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422504

Optimized gene transfer into human primary leukemic T cell with NOD-SCID/leukemia-initiating cell activity

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22897851

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22897851

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2012.06.007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22897851%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22897851%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22897851%20AND%20SRC:MED&resulttype=core&format=json