C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint (Q36188284)

12 August 2017

C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint (English)

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12 August 2017

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Jonathan R Hall

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12 August 2017

Michael S Bereman

2

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12 August 2017

Angelito I Nepomuceno

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12 August 2017

Elizabeth A Thompson

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12 August 2017

David C Muddiman

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12 August 2017

Robert C Smart

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12 August 2017

1 January 2014

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12 August 2017

9

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inferred from page(s)

published in

Cell Cycle

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12 August 2017

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22

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12 August 2017

3602-3610

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4614632/fullTextXML

inferred from PubMed Central ID database lookup

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CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration

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C/EBPα expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPα confers susceptibility to UVB-induced skin squamous cell carcinomas

1 October 2017

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SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

1 October 2017

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1 October 2017

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CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation

1 October 2017

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1 October 2017

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The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

1 October 2017

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PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

1 October 2017

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CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

1 October 2017

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Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7.

1 October 2017

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Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

1 October 2017

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

1 October 2017

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L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage

1 October 2017

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PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination

1 October 2017

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C/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes

1 October 2017

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1 October 2017

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Role of p21WAF1 in the cellular response to UV.

1 October 2017

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Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block

1 October 2017

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1 October 2017

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UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer

1 October 2017

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E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

1 October 2017

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Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

1 October 2017

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C/EBPalpha inhibits cell growth via direct repression of E2F-DP-mediated transcription

1 October 2017

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C/EBPbeta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression

1 October 2017

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 October 2017

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Transcription factor C/EBPalpha: novel sites of expression and cloning of the human gene

1 October 2017

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CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

1 October 2017

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Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

1 October 2017

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p21 is a universal inhibitor of cyclin kinases

1 October 2017

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WAF1, a potential mediator of p53 tumor suppression

1 October 2017

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 October 2017

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 October 2017

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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

1 October 2017

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Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair

1 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614632

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614632

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

1 October 2017

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Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in skin neoplasms

1 October 2017

1 reference

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2 July 2018

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Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

2 July 2018

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2 July 2018

1 reference

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A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination

22 September 2018

1 reference

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BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines

22 September 2018

1 reference

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Isolation and characterization of TAF25, an essential yeast gene that encodes an RNA polymerase II-specific TATA-binding protein-associated factor

22 September 2018

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https://api.crossref.org/works/10.4161%2F15384101.2014.962957

Attach first, then detach: a role for cyclin B-dependent kinase 1 in coordinating proteolysis with spindle assembly

21 January 2018

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https://api.crossref.org/works/10.4161%2F15384101.2014.962957

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

21 January 2018

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p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25483090

12 December 2020

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Role of p21(Waf-1) in regulating the G1 and G2/M checkpoints in ultraviolet-irradiated keratinocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25483090

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.4161/15384101.2014.962957

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

25483090

1 reference