Use of protease proteomics to discover granzyme B substrates (Q36232693)

12 August 2017

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title

Use of protease proteomics to discover granzyme B substrates (English)

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12 August 2017

Andrew J Bredemeyer

1

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12 August 2017

R Reid Townsend

series ordinal

2

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12 August 2017

Timothy J Ley

series ordinal

3

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12 August 2017

publication date

1 January 2005

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12 August 2017

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12 August 2017

volume

32

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12 August 2017

issue

1-3

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12 August 2017

page(s)

143-153

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Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

12 August 2017

cites work

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12 December 2020

Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.

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12 December 2020

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates

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12 December 2020

Production of fully active recombinant murine granzyme B in yeast

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12 December 2020

Proteinases and their inhibitors in the immune system

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12 December 2020

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

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12 December 2020

Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

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12 December 2020

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

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12 December 2020

DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

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12 December 2020

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

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12 December 2020

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

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12 December 2020

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

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12 December 2020

A proteomic approach for the discovery of protease substrates

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12 December 2020

Matrix metalloproteinases as modulators of inflammation and innate immunity

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12 December 2020

Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice

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12 December 2020

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

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12 December 2020

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

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12 December 2020

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

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12 December 2020

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

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12 December 2020

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

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12 December 2020

Cell death induced by granzyme C.

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12 December 2020

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

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12 December 2020

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

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12 December 2020

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

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12 December 2020

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

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12 December 2020

Lymphocyte-mediated cytotoxicity.

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12 December 2020

Granzyme M mediates a novel form of perforin-dependent cell death

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12 December 2020

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

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12 December 2020

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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12 December 2020

Defining protease specificity with proteomics: a protease with a dibasic amino acid recognition motif is regulated by a two-component signal transduction system in Salmonella

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12 December 2020

HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

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12 December 2020

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

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12 December 2020

Gelatinase B functions as regulator and effector in leukocyte biology

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12 December 2020

Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

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12 December 2020

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

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12 December 2020

Difference gel electrophoresis: a single gel method for detecting changes in protein extracts

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12 December 2020

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition

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12 December 2020

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

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12 December 2020

Definition and redesign of the extended substrate specificity of granzyme B.

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12 December 2020

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

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12 December 2020

Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology

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12 December 2020

Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis

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12 December 2020

Protease degradomics: a new challenge for proteomics

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12 December 2020

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

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12 December 2020

Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control

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12 December 2020

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

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12 December 2020

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

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12 December 2020

Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals

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12 December 2020

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

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12 December 2020

Identifiers

DOI

10.1385/IR:32:1-3:143

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Dimensions Publication ID

12 August 2017

1006157269

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