Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b (Q36252532)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

2

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6 March 2020

author name string

Naga Suresh Adapala

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Alexander Y Tsygankov

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Joseph A Lorenzo

4

1 reference

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6 March 2020

Archana Sanjay

5

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6 March 2020

publication date

1 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json

Journal of Cellular Biochemistry

6 March 2020

published in

1 reference

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6 March 2020

volume

115

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6 March 2020

page(s)

1277-1289

1 reference

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6 March 2020

issue

7

1 reference

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E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis

6 March 2020

cites work

1 reference

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Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation

30 September 2017

1 reference

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The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival

30 September 2017

1 reference

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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Cbl-phosphatidylinositol 3 kinase interaction differentially regulates macrophage colony-stimulating factor-mediated osteoclast survival and cytoskeletal reorganization

30 September 2017

1 reference

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Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia

30 September 2017

1 reference

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The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

30 September 2017

1 reference

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Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

30 September 2017

1 reference

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Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action

30 September 2017

1 reference

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Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

30 September 2017

1 reference

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Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation

30 September 2017

1 reference

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The Cbl family proteins: ring leaders in regulation of cell signaling

30 September 2017

1 reference

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The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function

30 September 2017

1 reference

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c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses

30 September 2017

1 reference

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Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation

30 September 2017

1 reference

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Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation

30 September 2017

1 reference

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The expanding role of PI3-kinase in bone.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Src kinase activity is essential for osteoclast function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Regulation of Raf-Akt Cross-talk

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Bone resorption by osteoclasts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

Cbl-b regulates the CD28 dependence of T-cell activation.

30 September 2017

1 reference

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

30 September 2017

1 reference

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Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

30 September 2017

1 reference

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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4634568

c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway

30 September 2017

1 reference

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Recognition and specificity in protein tyrosine kinase-mediated signalling

30 September 2017

1 reference

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Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts

30 September 2017

1 reference

Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.

21 January 2018

1 reference

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

21 January 2018

1 reference

Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport.

21 January 2018

1 reference

ZIP codes for delivering SH2 domains

21 January 2018

1 reference

Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor

21 January 2018

1 reference

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24470255

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24470255

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/JCB.24779

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24470255%20AND%20SRC:MED&resulttype=core&format=json