Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases (Q35126873)

6 August 2017

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title

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases (English)

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6 August 2017

Klaus Okkenhaug

2

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ORCID Public Data File 2021

author name string

Lazaros C Foukas

series ordinal

1

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PubMed ID

12745249

6 August 2017

language of work or name

English

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publication date

1 June 2003

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Archives of Biochemistry and Biophysics

6 August 2017

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6 August 2017

414

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6 August 2017

1

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6 August 2017

13-18

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Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Phosphatidylinositol-3-OH kinase as a direct target of Ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Activation of phosphoinositide 3-kinase gamma by Ras.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Phosphoinositide 3-kinase in immunological systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Phosphoinositide 3-kinases in immunity: lessons from knockout mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Synthesis and function of 3-phosphorylated inositol lipids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Lipids on the move: phosphoinositide 3-kinases in leukocyte function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Resistance to thromboembolism in PI3Kgamma-deficient mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Weakening link to colorectal cancer?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Pten is essential for embryonic development and tumour suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

PTEN regulation of neural development and CNS stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

The lipid phosphatase SHIP2 controls insulin sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900177-2

10.1016/S0003-9861(03)00177-2

7 January 2021

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12745249