Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis (Q36268287)

13 August 2017

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title

Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis (English)

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13 August 2017

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Marina Ulanova

1

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13 August 2017

Florentina Duta

2

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13 August 2017

Lakshmi Puttagunta

3

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13 August 2017

Alan D Schreiber

4

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13 August 2017

A Dean Befus

5

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13 August 2017

language of work or name

English

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publication date

1 October 2005

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Expert Opinion on Therapeutic Targets

13 August 2017

published in

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13 August 2017

volume

9

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13 August 2017

issue

5

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13 August 2017

page(s)

901-921

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Protein tyrosine kinase Syk in mast cell signaling

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The spleen tyrosine kinase (Syk) in human disease, implications for design of tyrosine kinase inhibitor based therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Targeting Syk as a treatment for allergic and autoimmune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The tandem Src homology 2 domain of the Syk kinase: a molecular device that adapts to interphosphotyrosine distances

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Collagen receptor signalling in platelets: extending the role of the ITAM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Vav3 regulates osteoclast function and bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Monocyte chemoattractant protein (MCP)-1 production via functionally reconstituted Fc? receptor (CD89) on glomerular mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Syk tyrosine kinase required for mouse viability and B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Molecular Characterization of the Murine SYK Protein Tyrosine Kinase cDNA, Transcripts and Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

A Ras activation pathway dependent on Syk phosphorylation of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The Fc receptor for IgA (FcalphaRI, CD89)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Lyn and Syk kinases are sequentially engaged in phagocytosis mediated by Fc gamma R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The Syk family of protein tyrosine kinases in T-cell activation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Lysosome is a primary organelle in B cell receptor-mediated apoptosis: an indispensable role of Syk in lysosomal function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Human NK cells express Fc receptors for IgA which mediate signal transduction and target cell killing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Natural killer cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Molecular adapters in Fc(epsilon)RI signaling and the allergic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Transmembrane adaptor proteins: organizers of immunoreceptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Proteasome-dependent regulation of Syk tyrosine kinase levels in human basophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Loss of syk kinase during IgE-mediated stimulation of human basophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Physical and functional interaction between p72(syk) and erythropoietin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

IL-1 induced chemokine production through the association of Syk with TNF receptor-associated factor-6 in nasal fibroblast lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Structure and function of Syk protein-tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Integrins: bidirectional, allosteric signaling machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Syk is required for integrin signaling in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Platelet adhesion signalling and the regulation of thrombus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Phosphatidylinositol 3-kinase mediates the inhibitory effect of epidermal growth factor on calcium-dependent chloride secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Multiple signals converging on NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

AP-1 function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Toll-like receptors in the induction of the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Regulation of K-Cl cotransport by Syk and Src protein tyrosine kinases in deoxygenated sickle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Progressive loss of Syk and abnormal proliferation in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Innovations in oligonucleotide drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

An update on the asthma-rhinitis link

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Atopic march: link to upper airways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Simultaneous treatment of asthma and allergic rhinitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The unified immune system: respiratory tract-nasobronchial interaction mechanisms in allergic airway disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Airway function and nasal inflammation in seasonal allergic rhinitis and asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Therapeutic strategies for allergic airways diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Immune regulation by histamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Inhibition of syk activity and degranulation of human mast cells by flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Potent small molecule inhibitors of spleen tyrosine kinase (Syk).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Signalling through the high-affinity IgE receptor Fc epsilonRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

Signal transduction by the TCR for antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

B cell antigen receptor signaling 101.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.901

The IL-15R alpha chain signals through association with Syk in human B cells

21 January 2018

1 reference

12 January 2024

https://opencitations.net/index/api/v1/citations/10.4049/JIMMUNOL.167.11.6292

Identifiers

DOI

10.1517/14728222.9.5.901

1 reference

13 August 2017

1 reference