Wnt signalling pathway: a new target for the treatment of osteoporosis (Q36268339)

13 August 2017

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title

Wnt signalling pathway: a new target for the treatment of osteoporosis (English)

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13 August 2017

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2

Sergio Roman-Roman

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author name string

Georges Rawadi

series ordinal

1

1 reference

PubMed ID

16185158

13 August 2017

Sergio Roman-Roman

series ordinal

2

1 reference

PubMed ID

16185158

13 August 2017

language of work or name

English

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publication date

1 October 2005

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Expert Opinion on Therapeutic Targets

13 August 2017

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13 August 2017

9

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13 August 2017

5

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13 August 2017

1063-1077

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Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling

13 August 2017

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https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Control of osteoblast function and regulation of bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

LRP5 and Wnt signaling: a union made for bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Wnt proteins are lipid-modified and can act as stem cell growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The promise and perils of Wnt signaling through beta-catenin.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Casein kinase Iepsilon modulates the signaling specificities of dishevelled

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Antagonist activity of DWnt-4 and wingless in the Drosophila embryonic ventral ectoderm and in heterologous Xenopus assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A new member of the frizzled family from Drosophila functions as a Wingless receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A member of the Frizzled protein family mediating axis induction by Wnt-5A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Interaction of Frizzled 7 and Dishevelled in Xenopus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Frizzleds: new members of the superfamily of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Modulation of wingless signaling by Notch in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

An LDL-receptor-related protein mediates Wnt signalling in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Regulation of patched by sonic hedgehog in the developing neural tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Induction of Smad6 mRNA by bone morphogenetic proteins

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Smad6 inhibits signalling by the TGF-beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Mechanisms of Wnt signaling in development

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The Wnt signaling pathway in development and disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Drosophila Tcf and Groucho interact to repress Wingless signalling activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Groucho/TLE family proteins and transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Naked cuticle targets dishevelled to antagonize Wnt signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts -3A, -5A, or -11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Secreted antagonists of the Wnt signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A new secreted protein that binds to Wnt proteins and inhibits their activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Functional and structural diversity of the human Dickkopf gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Proposal for a unified CCN nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Wise, a context-dependent activator and inhibitor of Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Increased bone formation and decreased osteocalcin expression induced by reduced Twist dosage in Saethre-Chotzen syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A twist code determines the onset of osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Signal transduction pathways regulating osteoclast differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Mechanistic insight into osteoclast differentiation in osteoimmunology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

High bone density due to a mutation in LDL-receptor-related protein 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

High bone mass in mice expressing a mutant LRP5 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Regulation of osteoblastogenesis and bone mass by Wnt10b

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The natural history of sclerosteosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Identification of genes regulated during osteoblastic differentiation by genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Aequorin-Based Functional Assays for G-Protein-Coupled Receptors, Ion Channels, and Tyrosine Kinase Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Frizzled6 controls hair patterning in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.1063

10.1517/14728222.9.5.1063

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16185158