Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2). (Q36283829)

13 August 2017

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2). (English)

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13 August 2017

2

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2 June 2020

Henrik Hammarén

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2 June 2020

author name string

Xiaoshan Min

1

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2 June 2020

Sarah Maxwell

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2 June 2020

Steve Thibault

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2 June 2020

Ellin-Kristina Hillert

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2 June 2020

Merrill Ayres

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2 June 2020

Brad Greenfield

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2 June 2020

John Eksterowicz

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2 June 2020

Chris Gabel

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2 June 2020

Nigel Walker

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2 June 2020

Olli Silvennoinen

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2 June 2020

Zhulun Wang

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2 June 2020

language of work or name

English

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publication date

10 September 2015

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Journal of Biological Chemistry

13 August 2017

10

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based on heuristic

inferred from page(s)

published in

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2 June 2020

volume

290

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2 June 2020

issue

45

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2 June 2020

page(s)

27261-27270

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Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

2 June 2020

cites work

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Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

30 September 2017

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A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

30 September 2017

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TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

30 September 2017

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Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

30 September 2017

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

30 September 2017

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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

30 September 2017

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Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity

30 September 2017

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Pseudokinases-remnants of evolution or key allosteric regulators?

30 September 2017

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ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

30 September 2017

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ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

30 September 2017

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30 September 2017

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The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

30 September 2017

1 reference

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Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

30 September 2017

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Emerging roles of pseudokinases

30 September 2017

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JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

30 September 2017

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The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

30 September 2017

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

30 September 2017

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

30 September 2017

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30 September 2017

The Janus kinases (Jaks)

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30 September 2017

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Refinement of macromolecular structures by the maximum-likelihood method

30 September 2017

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30 September 2017

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A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.

30 September 2017

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Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

30 September 2017

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The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

30 September 2017

1 reference

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Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

30 September 2017

1 reference

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Partial impairment of cytokine responses in Tyk2-deficient mice

30 September 2017

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A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling

30 September 2017

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Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

30 September 2017

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Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1.

30 September 2017

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Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo

30 September 2017

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Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation

30 September 2017

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Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase

30 September 2017

1 reference

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The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

30 September 2017

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Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

30 September 2017

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Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.

30 September 2017

1 reference

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Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway

30 September 2017

1 reference

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A protein tyrosine kinase in the interferon alpha/beta signaling pathway

30 September 2017

1 reference

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Conserved spatial patterns across the protein kinase family

30 September 2017

1 reference

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The receptor interaction region of Tyk2 contains a motif required for its nuclear localization.

22 September 2018

1 reference

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22 September 2018

Identifiers

DOI

10.1074/JBC.M115.672048

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26359499%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

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2 June 2020

PubMed publication ID

26359499

1 reference