The thiopurines: an update (Q36305435)

13 August 2017

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title

The thiopurines: an update (English)

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13 August 2017

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ChEBI release 2020-05-28

Sally Coulthard

1

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13 August 2017

Linda Hogarth

series ordinal

2

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13 August 2017

publication date

1 December 2005

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Investigational New Drugs

13 August 2017

published in

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13 August 2017

volume

23

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13 August 2017

issue

6

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13 August 2017

page(s)

523-532

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Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients

13 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS10637-005-4020-8

Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-005-4020-8

Recent advances in the pharmacogenomics of thiopurine methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-005-4020-8

Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-005-4020-8

Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-005-4020-8

Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6‐mercaptopurine and azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-005-4020-8

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-005-4020-8

Mercaptopurine vs thioguanine for the treatment of acute lymphoblastic leukemia

21 January 2018

1 reference

12 December 2020

Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia

1 reference

12 December 2020

Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: a comparison of haematological toxicity and drug metabolite concentrations

1 reference

12 December 2020

Thiopurine S-methyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate

1 reference

12 December 2020

Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity

1 reference

12 December 2020

Characterization of the DNA damage in 6-thioguanine-treated cells

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12 December 2020

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

1 reference

12 December 2020

High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.

1 reference

12 December 2020

The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia

1 reference

12 December 2020

Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation

1 reference

12 December 2020

The clinical pharmacology of 6-mercaptopurine

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12 December 2020

High incidence of secondary brain tumours after radiotherapy and antimetabolites.

1 reference

12 December 2020

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C

1 reference

12 December 2020

Molecular dosimetry of sister chromatid exchange induction in 9L cells treated with 6-thioguanine

1 reference

12 December 2020

6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells

1 reference

12 December 2020

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

1 reference

12 December 2020

In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase

1 reference

12 December 2020

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine

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12 December 2020

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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12 December 2020

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12 December 2020

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

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12 December 2020

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

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12 December 2020

Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression

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12 December 2020

Thiopurine methyltransferase phenotypes and genotypes in Brazilians

1 reference

12 December 2020

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity

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12 December 2020

Mechanisms of tolerance to DNA damaging therapeutic drugs

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12 December 2020

Genetic polymorphism of thiopurine S-methyltransferase in Argentina

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12 December 2020

Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism

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12 December 2020

Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

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12 December 2020

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

1 reference

12 December 2020

Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides

1 reference

12 December 2020

Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians

1 reference

12 December 2020

Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis

1 reference

12 December 2020

Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1

1 reference

12 December 2020

Characterization of three new VNTR alleles in the promoter region of the TPMT gene

1 reference

12 December 2020

Segregation analysis of human red blood cell thiopurine methyltransferase activity

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12 December 2020

Olsalazine and 6-mercaptopurine-related bone marrow suppression: a possible drug-drug interaction

1 reference

12 December 2020

Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter.

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12 December 2020

Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population

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12 December 2020

Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity

1 reference

12 December 2020

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

1 reference

12 December 2020

Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

1 reference

12 December 2020

Balsalazide and azathiprine or 6-mercaptopurine: evidence for a potentially serious drug interaction

1 reference

12 December 2020

Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine

1 reference

12 December 2020

Individualized dosages of chemotherapy as a strategy to improve response for acute lymphocytic leukemia

1 reference

12 December 2020

Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases

1 reference

12 December 2020

Human lymphocyte thiopurine methyltransferase pharmacogenetics: effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation

1 reference

12 December 2020

The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia

1 reference

12 December 2020

The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs

1 reference

12 December 2020

Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89 and 92

1 reference

12 December 2020

Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues

1 reference

12 December 2020

Unilateral chromatid damage: a new basis for 6-thioguanine cytotoxicity.

1 reference

12 December 2020

Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia

1 reference

12 December 2020

The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts

1 reference

12 December 2020

Clinical pharmacologic observations on 6-mercaptopurine and 6-methylthiopurine ribonucleoside

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12 December 2020

Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey

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12 December 2020

Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis

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12 December 2020

Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter

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12 December 2020

Phase II evaluation and plasma pharmacokinetics of high-dose intravenous 6-thioguanine in patients with colorectal carcinoma

1 reference

12 December 2020

Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene

1 reference

12 December 2020

Secondary brain tumours in children with ALL

1 reference

12 December 2020

Clinical pharmacology of oral thioguanine in acute myelogenous leukemia

1 reference

12 December 2020

Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm

1 reference

12 December 2020

Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.

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12 December 2020

Improving the curability of acute leukemia: pharmacologic approaches

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12 December 2020

Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.

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12 December 2020

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

1 reference

12 December 2020

Differential chromatid damage induced by 6-thioguanine in CHO cells

1 reference

12 December 2020

A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL.

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12 December 2020

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

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12 December 2020

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

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12 December 2020

Prolonged survival of human-kidney homografts by immunosuppressive drug therapy

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12 December 2020

Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?

1 reference

12 December 2020

The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase

1 reference

12 December 2020

Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia

1 reference

12 December 2020

Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide

1 reference

12 December 2020

A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations

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12 December 2020

Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates.

1 reference

12 December 2020

TPMT in the treatment of inflammatory bowel disease with azathioprine

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12 December 2020

Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukemia

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12 December 2020

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.

1 reference

12 December 2020

Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library

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12 December 2020

Cellular pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia

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12 December 2020

Pharmacology of 6-thioguanine in man.

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12 December 2020

Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

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12 December 2020

Thiopurine methyltransferase levels should be measured before commencing patients on azathioprine

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12 December 2020

Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia

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12 December 2020

Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease

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12 December 2020

10.1007/S10637-005-4020-8

Identifiers

DOI

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13 August 2017

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