Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands (Q36335446)

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English	Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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cannabinoid receptor

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author name string

Krishna C Chimalakonda

1

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Europe PubMed Central

PMC publication ID

13 August 2017

Kathryn A Seely

2

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Europe PubMed Central

PMC publication ID

13 August 2017

Stacie M Bratton

3

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Europe PubMed Central

PMC publication ID

13 August 2017

Lisa K Brents

4

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Europe PubMed Central

PMC publication ID

13 August 2017

Cindy L Moran

5

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Europe PubMed Central

PMC publication ID

13 August 2017

Gregory W Endres

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Laura P James

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Paul F Hollenberg

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Paul L Prather

9

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Anna Radominska-Pandya

10

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jeffery H Moran

11

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Europe PubMed Central

PMC publication ID

13 August 2017

publication date

17 August 2012

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Europe PubMed Central

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13 August 2017

Drug Metabolism and Disposition

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Europe PubMed Central

PMC publication ID

13 August 2017

40

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Europe PubMed Central

PMC publication ID

13 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

2174-2184

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Severe toxicity following synthetic cannabinoid ingestion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

College students and use of K2: an emerging drug of abuse in young persons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

The "new" marijuana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Synthetic cannabinoid JWH-018 and psychosis: an explorative study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

"Spice" girls: synthetic cannabinoid intoxication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Detection of JWH-018 metabolites in smoking mixture post-administration urine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Withdrawal phenomena and dependence syndrome after the consumption of "spice gold"

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Cannabinoid receptors: where they are and what they do.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Expression and function of cytochrome p450 in brain drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

The cannabis withdrawal syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

The human intestinal cytochrome P450 "pie".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

CB1 cannabinoid receptor ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Drug abuse trends among youth in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

The complexities of the cardiovascular actions of cannabinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Cardiovascular system effects of marijuana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

In vitro metabolism of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a cannabinoid receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Cannabis: pharmacology and toxicology in animals and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

30 September 2017

Human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

29 June 2018

In vitro phase I metabolism of the synthetic cannabimimetic JWH-018.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

22 September 2018

A teenager with agitation: higher than she should have climbed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

22 September 2018

The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

22 September 2018

Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

22 September 2018

CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477201

22 September 2018

Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potencies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoalkylindoles (AAIs): a new route to the cannabinoid receptor?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitive determination of delta 9-tetrahydrocannabinol in human tissues by GC-MS

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of CYP2C in the metabolism of cannabinoids by human hepatic microsomes from an old woman

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intoxication from smoking "spice"

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic cannabinoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychiatric sequelae of Spice, K2, and synthetic cannabinoid receptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three cases of "spice" exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in human whole blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterants in ‘herbal mixtures’ using LC-MS/MS techniques

1 reference

https://pubmed.ncbi.nlm.nih.gov/22904561

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.112.047530

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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