Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors (Q40529215)

21 September 2017

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors (English)

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21 September 2017

Proctor NJ

1

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21 September 2017

Tucker GT

series ordinal

2

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21 September 2017

Rostami-Hodjegan A

series ordinal

3

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21 September 2017

language of work or name

English

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publication date

1 February 2004

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21 September 2017

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21 September 2017

34

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21 September 2017

2

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21 September 2017

151-178

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Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1.

21 September 2017

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Role of human liver microsomal CYP2C9 in the biotransformation of lornoxicam

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

In vitro forecasting of drugs which may interfere with the biotransformation of midazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Biotransformation of caffeine by cDNA-expressed human cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Assay and characterisation of debrisoquine 4-hydroxylase activity of microsomal fractions of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Regioselectivity and enantioselectivity of metoprolol oxidation by two variants of cDNA-expressed P4502D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Involvement of CYP1A2 in mexiletine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expressi

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Tolbutamide 4-hydroxylase activity of human liver microsomes: effect of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Inhibitors of imipramine metabolism by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Relative quantities of catalytically active CYP 2C9 and 2C19 in human liver microsomes: application of the relative activity factor approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Effects of metronidazole on midazolam metabolism in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Plasma concentrations of active simvastatin acid are increased by gemfibrozil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine-type polymorphism of drug oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250310001646353

10.1080/00498250310001646353

21 January 2018

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DOI

1 reference

21 September 2017

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