Modeling age-related diseases in Drosophila: can this fly? (Q36339275)

13 August 2017

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title

Modeling age-related diseases in Drosophila: can this fly? (English)

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13 August 2017

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Kinga Michno

1

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13 August 2017

Diana van de Hoef

series ordinal

2

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13 August 2017

Hong Wu

series ordinal

3

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13 August 2017

Gabrielle L Boulianne

series ordinal

4

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13 August 2017

publication date

1 January 2005

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Current Topics in Developmental Biology

13 August 2017

published in

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13 August 2017

volume

71

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13 August 2017

page(s)

199-223

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A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

13 August 2017

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The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system.

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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Dying for a cause: invertebrate genetics takes on human neurodegeneration

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Expression of human FALS SOD in motorneurons of Drosophila.

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7 January 2021

Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

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7 January 2021

A Drosophila model of Parkinson's disease

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7 January 2021

Identification of genes that modify ataxin-1-induced neurodegeneration.

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7 January 2021

A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster

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7 January 2021

A survey of human disease gene counterparts in the Drosophila genome

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7 January 2021

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

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7 January 2021

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

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7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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7 January 2021

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.

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7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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7 January 2021

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

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7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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7 January 2021

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Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

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7 January 2021

Alzheimer Disease in the US Population

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7 January 2021

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

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7 January 2021

Polyglutamine disease: acetyltransferases awry

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7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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7 January 2021

Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

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7 January 2021

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

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7 January 2021

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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7 January 2021

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors

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7 January 2021

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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7 January 2021

Genetic suppression of polyglutamine toxicity in Drosophila

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7 January 2021

Epitopes that span the tau molecule are shared with paired helical filaments.

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7 January 2021

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

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7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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7 January 2021

Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila

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7 January 2021

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

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7 January 2021

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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7 January 2021

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

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7 January 2021

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

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7 January 2021

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

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7 January 2021

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

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7 January 2021

Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease

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7 January 2021

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene

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7 January 2021

Fast calcium signals in Drosophila motor neuron terminals.

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7 January 2021

Fly models of Huntington's disease

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7 January 2021

Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

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7 January 2021

Phenotypic effects of familial amyotrophic lateral sclerosis mutant Sod alleles in transgenic Drosophila

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7 January 2021

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

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7 January 2021

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

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7 January 2021

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

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https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2971006-1

7 January 2021

Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2971006-1

7 January 2021

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

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7 January 2021

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

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7 January 2021

Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

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7 January 2021

CAG repeat number governs the development rate of pathology in Huntington's disease

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7 January 2021

Glutamine repeats and neurodegenerative diseases: molecular aspects

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7 January 2021

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity

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7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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7 January 2021

Genetic neurodegenerative diseases: the human illness and transgenic models

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7 January 2021

Alzheimer's disease: genetic studies and transgenic models

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7 January 2021

Alzheimer's disease: a description of the structural lesions

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7 January 2021

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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7 January 2021

A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster

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7 January 2021

Phenotypic rescue by a bovine transgene in a Cu/Zn superoxide dismutase-null mutant of Drosophila melanogaster

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7 January 2021

Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain.

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7 January 2021

The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages.

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7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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7 January 2021

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

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7 January 2021

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

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7 January 2021

Comparative genomics of the eukaryotes

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7 January 2021

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

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7 January 2021

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

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7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

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7 January 2021

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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7 January 2021

Alpha-synuclein in Lewy bodies

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7 January 2021

SUMO modification of Huntingtin and Huntington's disease pathology

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7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2971006-1

7 January 2021

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2971006-1

7 January 2021

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

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https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2971006-1

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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7 January 2021

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

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7 January 2021

Potassium bromide, an anticonvulsant, is effective at alleviating seizures in the Drosophila bang-sensitive mutant bang senseless.

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7 January 2021

The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

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7 January 2021

The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

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7 January 2021

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

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7 January 2021

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2971006-1

7 January 2021

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

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https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2971006-1

7 January 2021

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

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7 January 2021

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

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7 January 2021

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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7 January 2021

Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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7 January 2021

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

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7 January 2021

10.1016/S0070-2153(05)71006-1

Identifiers

DOI

1 reference

13 August 2017

1 reference