Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. (Q44854880)

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27 December 2019

title

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila (English)

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27 December 2019

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2

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27 December 2019

author name string

Isabell Greeve

1

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27 December 2019

Jakob-Andreas Tschäpe

3

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Anika Beyn

4

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27 December 2019

Claire Brellinger

5

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27 December 2019

Michaela Schweizer

6

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Roger M Nitsch

7

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Rita Reifegerste

8

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language of work or name

English

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publication date

1 April 2004

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27 December 2019

published in

Journal of Neuroscience

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27 December 2019

volume

24

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27 December 2019

issue

16

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27 December 2019

page(s)

3899-3906

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

27 December 2019

cites work

1 reference

12 December 2020

Translating cell biology into therapeutic advances in Alzheimer's disease

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12 December 2020

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer.

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12 December 2020

The genome sequence of Drosophila melanogaster

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12 December 2020

Proteolytic processing and cell biological functions of the amyloid precursor protein

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Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway

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12 December 2020

Studying human neurodegenerative diseases in flies and worms

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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12 December 2020

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

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12 December 2020

The role of post-translational modification in beta-amyloid precursor protein processing

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12 December 2020

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

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12 December 2020

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

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12 December 2020

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

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12 December 2020

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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12 December 2020

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

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12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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12 December 2020

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

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12 December 2020

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

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12 December 2020

Transposition of cloned P elements into Drosophila germ line chromosomes.

1 reference

12 December 2020

Genetic Transformation of Drosophila with Transposable Element Vectors

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12 December 2020

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

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12 December 2020

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons.

1 reference

12 December 2020

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

12 December 2020

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

1 reference

12 December 2020

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that int

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12 December 2020

A role for the beta-amyloid precursor protein in memory?

1 reference

12 December 2020

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

1 reference

12 December 2020

10.1523/JNEUROSCI.0283-04.2004

Identifiers

DOI

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