BH3-only proteins: integrated control point of apoptosis (Q36435312)

14 August 2017

BH3-only proteins: integrated control point of apoptosis (English)

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14 August 2017

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Tsukasa Shibue

1

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PubMed ID

16572413

14 August 2017

Tadatsugu Taniguchi

series ordinal

2

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PubMed ID

16572413

14 August 2017

language of work or name

English

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publication date

1 November 2006

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International Journal of Cancer

14 August 2017

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14 August 2017

119

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9

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14 August 2017

2036-2043

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Ways of dying: multiple pathways to apoptosis.

14 August 2017

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Cell death: critical control points

21 January 2018

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21 January 2018

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The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

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Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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Proapoptotic BAX and BAK control multiple initiator caspases

21 January 2018

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

21 January 2018

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BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

21 January 2018

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

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PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

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PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

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harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

21 January 2018

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Functional dissection of the pro-apoptotic protein Bik. Heterodimerization with anti-apoptosis proteins is insufficient for induction of cell death

21 January 2018

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

21 January 2018

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

21 January 2018

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Survival signaling goes BAD.

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

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Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

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Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis

21 January 2018

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

21 January 2018

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Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 January 2018

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Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

21 January 2018

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Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

21 January 2018

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BID regulation by p53 contributes to chemosensitivity

21 January 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

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Proapoptotic BID is required for myeloid homeostasis and tumor suppression

21 January 2018

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

21 January 2018

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Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

21 January 2018

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

21 January 2018

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

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JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

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Bim is a suppressor of Myc-induced mouse B cell leukemia

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

21 January 2018

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

21 January 2018

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Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

21 January 2018

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

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Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

21 January 2018

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BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

21 January 2018

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Integral role of Noxa in p53-mediated apoptotic response

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

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Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death

21 January 2018

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Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

21 January 2018

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Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.

21 January 2018

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Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis

21 January 2018

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Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

21 January 2018

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

21 January 2018

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

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The mitochondrion in apoptosis: how Pandora's box opens

21 January 2018

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The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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The Bcl-2 family: roles in cell survival and oncogenesis.

21 January 2018

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

21 January 2018

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Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

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Suppression of tumorigenesis by the p53 target PUMA

21 January 2018

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.21751

1 reference

14 August 2017

1 reference

PubMed ID

16572413