Keynote review: allosterism in membrane receptors (Q36437496)

14 August 2017

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title

Keynote review: allosterism in membrane receptors (English)

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14 August 2017

Zhan-Guo Gao

1

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14 August 2017

Kenneth A Jacobson

series ordinal

2

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14 August 2017

publication date

1 March 2006

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14 August 2017

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14 August 2017

volume

11

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14 August 2017

issue

5-6

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14 August 2017

page(s)

191-202

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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

14 August 2017

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7 January 2021

Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding

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7 January 2021

2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors

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7 January 2021

Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain

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7 January 2021

Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism

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Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract Guanine nucleotide effects on agonist binding

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7 January 2021

Investigation of the Interaction of a Putative Allosteric Modulator,N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) Methanamine Hydrobromide (SCH-202676), with M1Muscarinic Acetylcholine Receptors

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7 January 2021

Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action

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7 January 2021

Allosteric modulation of A2A adenosine receptors by amiloride analogues and sodium ions

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7 January 2021

Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives

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7 January 2021

Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

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7 January 2021

Inhibition of the actions of carbachol and DFP on guinea pig isolated atria by alkane-bis-ammonium compounds

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7 January 2021

The inhibitory effect of gallamine on muscarinic receptors

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7 January 2021

Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors

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Muscarinic allosteric enhancers of ligand binding: pivotal pharmacophoric elements in hexamethonio-type agents

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7 January 2021

Discovery of an ectopic activation site on the M(1) muscarinic receptor

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7 January 2021

Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist

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7 January 2021

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Design and synthesis of photoaffinity-labeling ligands of the L-prolyl-L-leucylglycinamide binding site involved in the allosteric modulation of the dopamine receptor

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7 January 2021

Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

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7 January 2021

Chemokines: integrators of pain and inflammation

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7 January 2021

Identification of allosteric peptide agonists of CXCR4.

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7 January 2021

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

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7 January 2021

The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

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7 January 2021

Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA.

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7 January 2021

Positive allosteric modulator of the human 5-HT2C receptor

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7 January 2021

Antagonists and the purinergic nerve hypothesis: 2, 2'-pyridylisatogen tosylate (PIT), an allosteric modulator of P2Y receptors. A retrospective on a quarter century of progress

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7 January 2021

2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding

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7 January 2021

The oxytocin receptor system: structure, function, and regulation

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7 January 2021

Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors

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7 January 2021

Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists

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7 January 2021

Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptors

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7 January 2021

Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor

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7 January 2021

Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin

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7 January 2021

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

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7 January 2021

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine

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7 January 2021

Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

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7 January 2021

Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.

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7 January 2021

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

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7 January 2021

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7 January 2021

The cysteine-rich region of T1R3 determines responses to intensely sweet proteins

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7 January 2021

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7 January 2021

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7 January 2021

Positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (mGluR2).

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7 January 2021

Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system

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7 January 2021

Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5).

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7 January 2021

New therapeutic frontiers for metabotropic glutamate receptors

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7 January 2021

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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7 January 2021

Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

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7 January 2021

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7 January 2021

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

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7 January 2021

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

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7 January 2021

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

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7 January 2021

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

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7 January 2021

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

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7 January 2021

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia

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7 January 2021

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

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7 January 2021

Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results

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7 January 2021

Calcimimetics with potent and selective activity on the parathyroid calcium receptor

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7 January 2021

Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator

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7 January 2021

Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain

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7 January 2021

L-amino acid sensing by the extracellular Ca2+-sensing receptor

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7 January 2021

Modeling and Mutagenesis of the Binding Site of Calhex 231, a Novel Negative Allosteric Modulator of the Extracellular Ca2+-sensing Receptor

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7 January 2021

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.

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7 January 2021

A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo

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7 January 2021

Sodium and potassium salt stimulation of taste receptor cells: an allosteric model

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7 January 2021

Canine taste nerve responses to monosodium glutamate and disodium guanylate: differentiation between umami and salt components with amiloride

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7 January 2021

Introductory remarks on umami taste

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7 January 2021

A novel family of mammalian taste receptors

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7 January 2021

Allosteric receptors after 30 years

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7 January 2021

Allosteric modulation of ligand-gated ion channels

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7 January 2021

Modulation of P2X3 receptors by Mg2+ on rat DRG neurons in culture

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7 January 2021

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue

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7 January 2021

Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons

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7 January 2021

Alcohol action on membrane ion channels gated by extracellular ATP (P2X receptors).

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7 January 2021

An intersubunit zinc binding site in rat P2X2 receptors

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7 January 2021

P2X receptors: targets for novel analgesics?

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7 January 2021

Glutamate receptor ion channels

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7 January 2021

The micromolar zinc-binding domain on the NMDA receptor subunit NR2B.

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7 January 2021

Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors

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7 January 2021

The benzodiazepine site of the GABAA receptor: an old target with new potential?

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7 January 2021

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

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7 January 2021

GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

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7 January 2021

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

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7 January 2021

Nicotinic acetylcholine receptors as drug targets

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7 January 2021

Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR

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7 January 2021

Effect of galantamine on the human alpha7 neuronal nicotinic acetylcholine receptor, the Torpedo nicotinic acetylcholine receptor and spontaneous cholinergic synaptic activity

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7 January 2021

Tyrosine kinases as targets for cancer therapy

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7 January 2021

Signalling through the insulin receptor and the insulin-like growth factor-I receptor

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7 January 2021

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75

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7 January 2021

The yin and yang of neurotrophin action

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7 January 2021

p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

Small molecule Trk receptor agonists and other neurotrophic factor mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

Structural insights into the regulation and the activation mechanism of mammalian guanylyl cyclases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

NO-independent regulatory site on soluble guanylate cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903689-5

7 January 2021

10.1016/S1359-6446(05)03689-5

Identifiers

DOI

1 reference

14 August 2017

1 reference