What makes a good anti-inflammatory drug target? (Q36437505)

14 August 2017

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title

What makes a good anti-inflammatory drug target? (English)

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14 August 2017

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David L Simmons

1

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14 August 2017

1 March 2006

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14 August 2017

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14 August 2017

11

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14 August 2017

5-6

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14 August 2017

210-219

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The role of innovation in drug development

14 August 2017

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Cytokines and cytokine receptors

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The G protein-coupled receptor repertoires of human and mouse

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An endotoxin-induced serum factor that causes necrosis of tumors

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Tumor necrosis, cachexia, shock, and inflammation: a common mediator

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Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

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Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

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Molecular phylogeny within type I cytokines and their cognate receptors

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The Class II cytokine receptor (CRF2) family: overview and patterns of receptor-ligand interactions

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Interferons, interferon-like cytokines, and their receptors

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IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26.

1 reference

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The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain

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A sequence-based map of the nine genes of the human interleukin-1 cluster

1 reference

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IL-1 and IL-18 receptors, and their extended family.

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Interleukin-18: A novel cytokine in inflammatory rheumatic disease

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Interleukin-17 family and IL-17 receptors

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Modulation of TNF receptor family members to inhibit autoimmune disease

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Signalling pathways of the TNF superfamily: a double-edged sword

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The biology of IL-12: coordinating innate and adaptive immune responses

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Biology of IL-21 and the IL-21 receptor

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The role of IL-27 in the development of T-cell responses during parasitic infections

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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

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7 January 2021

Targeting leukocyte integrins in human diseases

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Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab

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Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

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The B7 family revisited

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The identification of ligands at orphan G-protein coupled receptors

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Characterization of the human cysteinyl leukotriene CysLT1 receptor

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Principles for modulation of the nuclear receptor superfamily

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7 January 2021

Aspirin and steroids: new mechanistic findings and avenues for drug discovery

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7 January 2021

Inflammatory resolution: new opportunities for drug discovery

1 reference

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7 January 2021

The structure of interleukin-2 complexed with its alpha receptor

1 reference

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7 January 2021

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

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7 January 2021

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Identifiers

DOI

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14 August 2017

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PubMed ID

16580598