Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation (Q36473356)

14 August 2017

Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation (English)

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14 August 2017

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Myriam Gorospe

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Josephine M Egan

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Olga D Carlson

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Wook Kim

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Qizong Lao

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14 August 2017

Yu-Kyong Shin

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14 August 2017

Eun Kyung Lee

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14 August 2017

Rohit N Kulkarni

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20 March 2012

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ra23

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describes a project that uses

14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3524575/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells

1 reference

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Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.

30 September 2017

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Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells

30 September 2017

1 reference

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The endocannabinoid system: role in glucose and energy metabolism

30 September 2017

1 reference

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Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding

30 September 2017

1 reference

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The role of the pancreatic endocannabinoid system in glucose metabolism.

30 September 2017

1 reference

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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

30 September 2017

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Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

30 September 2017

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Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program

30 September 2017

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Modulation of the endocannabinoid system by lipid rafts.

30 September 2017

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Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest

30 September 2017

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Cannabinoid receptors as novel targets for the treatment of melanoma

30 September 2017

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p16INK4a induces an age-dependent decline in islet regenerative potential

30 September 2017

1 reference

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Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia

30 September 2017

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Critical nodes in signalling pathways: insights into insulin action

30 September 2017

1 reference

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The emerging role of the endocannabinoid system in endocrine regulation and energy balance

30 September 2017

1 reference

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Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells

30 September 2017

1 reference

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Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice

30 September 2017

1 reference

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Cell death: critical control points

30 September 2017

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

30 September 2017

1 reference

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

30 September 2017

1 reference

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

30 September 2017

1 reference

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Leptin-regulated endocannabinoids are involved in maintaining food intake

30 September 2017

1 reference

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

30 September 2017

1 reference

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Structure and function of sphingolipid- and cholesterol-rich membrane rafts

30 September 2017

1 reference

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Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

30 September 2017

1 reference

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Cellular survival: a play in three Akts

30 September 2017

1 reference

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Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

30 September 2017

1 reference

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Disruption of IRS-2 causes type 2 diabetes in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

30 September 2017

1 reference

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

30 September 2017

1 reference

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Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Insulin-induced protein tyrosine phosphorylation cascade and signalling molecules are localized in a caveolin-enriched cell membrane domain.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

{beta}-Cell mass dynamics and islet cell plasticity in human type 2 diabetes.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Presence of functional cannabinoid receptors in human endocrine pancreas

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

p27 Regulates the transition of beta-cells from quiescence to proliferation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Relationship between beta-cell mass and fasting blood glucose concentration in humans

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

FoxO1a can alter cell cycle progression by regulating the nuclear localization of p27kip in granulosa cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524575

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22434934

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22434934

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.2002519

1 reference

14 August 2017

1 reference

14 August 2017

1 reference