TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. (Q36478806)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26702100%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion (English)

1 reference

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3 March 2020

0 references

7

1 reference

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3 March 2020

author name string

Qin Xia

1

1 reference

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3 March 2020

Hongfeng Wang

2

1 reference

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3 March 2020

Zongbing Hao

3

1 reference

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3 March 2020

Cheng Fu

4

1 reference

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3 March 2020

Qingsong Hu

5

1 reference

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3 March 2020

Feng Gao

6

1 reference

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3 March 2020

Dong Chen

8

1 reference

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3 March 2020

Junhai Han

9

1 reference

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3 March 2020

Zheng Ying

10

1 reference

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3 March 2020

Guanghui Wang

11

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3 March 2020

language of work or name

English

0 references

publication date

23 December 2015

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3 March 2020

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3 March 2020

volume

35

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3 March 2020

issue

2

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3 March 2020

page(s)

121-142

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describes a project that uses

3 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4718457/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification

1 reference

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ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

30 September 2017

1 reference

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Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.

30 September 2017

1 reference

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PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

30 September 2017

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Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

30 September 2017

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Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

30 September 2017

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Regulation of mTORC1 by amino acids

30 September 2017

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Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

30 September 2017

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The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17

30 September 2017

1 reference

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Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

30 September 2017

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Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy

30 September 2017

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Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

30 September 2017

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

30 September 2017

1 reference

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Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

30 September 2017

1 reference

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Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro

30 September 2017

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Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

30 September 2017

1 reference

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Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

30 September 2017

1 reference

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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

30 September 2017

1 reference

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mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy

30 September 2017

1 reference

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The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes

30 September 2017

1 reference

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

30 September 2017

1 reference

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TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans

30 September 2017

1 reference

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PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

30 September 2017

1 reference

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Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

30 September 2017

1 reference

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Does a loss of TDP-43 function cause neurodegeneration?

30 September 2017

1 reference

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

30 September 2017

1 reference

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

30 September 2017

1 reference

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Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span

30 September 2017

1 reference

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Control of autophagy as a therapy for neurodegenerative disease

30 September 2017

1 reference

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Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

30 September 2017

1 reference

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Regulation of TFEB and V-ATPases by mTORC1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Neuronal function and dysfunction of Drosophila dTDP

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

TFEB links autophagy to lysosomal biogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

mTOR: from growth signal integration to cancer, diabetes and ageing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Autophagy gone awry in neurodegenerative diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

A gene network regulating lysosomal biogenesis and function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Lysosomal positioning coordinates cellular nutrient responses.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718457

21 September 2018

Identifiers

DOI

10.15252/EMBJ.201591998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26702100%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26702100%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26702100%20AND%20SRC:MED&resulttype=core&format=json