Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis (Q34373108)

1 August 2017

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis (English)

1 reference

amyotrophic lateral sclerosis

1 August 2017

0 references

author

Melissa Nassif

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Diego Rojas-Rivera

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

8

Guido Kroemer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

9

Beth Levine

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Vicente Valenzuela

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

René Vidal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Soledad Matus

5

1 reference

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7 June 2020

Karen Castillo

6

1 reference

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7 June 2020

Yerko Fuentealba

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Claudio Hetz

10

1 reference

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7 June 2020

language of work or name

1 reference

12 May 2014

1 reference

1 August 2017

1 reference

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7 June 2020

volume

10

1 reference

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7 June 2020

page(s)

1256-1271

1 reference

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7 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

The epidemiology of ALS: a conspiracy of genes, environment and time

7 June 2020

cites work

1 reference

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Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis

6 July 2018

1 reference

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

6 July 2018

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PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage

6 July 2018

1 reference

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The changing scene of amyotrophic lateral sclerosis

6 July 2018

1 reference

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

6 July 2018

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Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

6 July 2018

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Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation

6 July 2018

1 reference

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Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: a new light for treatment of TARDBP/TDP-43 proteinopathies

6 July 2018

1 reference

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SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 July 2018

1 reference

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Guidelines for the use and interpretation of assays for monitoring autophagy

6 July 2018

1 reference

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Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

6 July 2018

1 reference

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Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro

6 July 2018

1 reference

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Hormesis: protecting neurons against cellular stress in Parkinson disease

6 July 2018

1 reference

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The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.

6 July 2018

1 reference

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Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

6 July 2018

1 reference

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Activation of the unfolded protein response enhances motor recovery after spinal cord injury

6 July 2018

1 reference

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Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways

6 July 2018

1 reference

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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

6 July 2018

1 reference

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Control of autophagy as a therapy for neurodegenerative disease

6 July 2018

1 reference

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Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

6 July 2018

1 reference

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

6 July 2018

1 reference

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

6 July 2018

1 reference

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Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

6 July 2018

1 reference

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Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

6 July 2018

1 reference

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Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

6 July 2018

1 reference

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Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

6 July 2018

1 reference

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Characterization of macroautophagic flux in vivo using a leupeptin-based assay

6 July 2018

1 reference

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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

6 July 2018

1 reference

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Protein misfolding disorders and macroautophagy

6 July 2018

1 reference

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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

6 July 2018

1 reference

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The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration

6 July 2018

1 reference

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Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

6 July 2018

1 reference

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The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

6 July 2018

1 reference

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

6 July 2018

1 reference

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ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

6 July 2018

1 reference

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

6 July 2018

1 reference

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Mutant superoxide dismutase 1 overexpression in NSC-34 cells: effect of trehalose on aggregation, TDP-43 localization and levels of co-expressed glycoproteins

6 July 2018

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Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

6 July 2018

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Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

6 July 2018

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The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

6 July 2018

1 reference

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Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

6 July 2018

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

6 July 2018

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Discovery of Atg5/Atg7-independent alternative macroautophagy

6 July 2018

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6 July 2018

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Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

6 July 2018

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

6 July 2018

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Autophagy suppresses tumorigenesis through elimination of p62

6 July 2018

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6 July 2018

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BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

6 July 2018

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

6 July 2018

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

6 July 2018

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

6 July 2018

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

6 July 2018

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6 July 2018

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

6 July 2018

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

6 July 2018

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

6 July 2018

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Autophagy fights disease through cellular self-digestion

6 July 2018

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Autophagy in the Pathogenesis of Disease

6 July 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

6 July 2018

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Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.

6 July 2018

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Lipid trafficking defects increase Beclin-1 and activate autophagy in Niemann-Pick type C disease

6 July 2018

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p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis

6 July 2018

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ALS: a disease of motor neurons and their nonneuronal neighbors

6 July 2018

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

6 July 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

6 July 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

6 July 2018

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

6 July 2018

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

6 July 2018

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Opinion: What is the role of protein aggregation in neurodegeneration?

6 July 2018

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Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

6 July 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

6 July 2018

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Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

6 July 2018

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

6 July 2018

1 reference

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

6 July 2018

1 reference

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Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

6 July 2018

1 reference

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

6 July 2018

1 reference

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Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

6 July 2018

1 reference

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

6 July 2018

1 reference

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Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

6 July 2018

1 reference

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Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

6 July 2018

1 reference

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Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

6 July 2018

2 references

https://api.crossref.org/works/10.4161%2FAUTO.28784

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203551

In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis.

27 October 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Targeting autophagy in ALS: a complex mission

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Closed head injury induces upregulation of Beclin 1 at the cortical site of injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28784

Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

12 December 2020

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

1 reference

12 December 2020

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

1 reference

12 December 2020

Identifiers

DOI

10.4161/AUTO.28784

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905722%20AND%20SRC:MED&resulttype=core&format=json