Control of autophagy as a therapy for neurodegenerative disease (Q37970303)

26 August 2017

Control of autophagy as a therapy for neurodegenerative disease (English)

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26 August 2017

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Harry Harris

1

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26 August 2017

David C Rubinsztein

series ordinal

2

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26 August 2017

language of work or name

English

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publication date

20 December 2011

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26 August 2017

Nature Reviews Neurology

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26 August 2017

8

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26 August 2017

108-117

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26 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2011.200

26 August 2017

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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

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Plasma membrane contributes to the formation of pre-autophagosomal structures

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A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

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3D tomography reveals connections between the phagophore and endoplasmic reticulum

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Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae

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The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy

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Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae

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Mitochondria supply membranes for autophagosome biogenesis during starvation

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Autophagosome precursor maturation requires homotypic fusion

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A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy

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Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

21 January 2018

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Lysosomes: fusion and function

21 January 2018

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Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes

21 January 2018

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Growing roles for the mTOR pathway

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JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

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Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein

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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

21 January 2018

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The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.

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Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

21 January 2018

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Opinion: What is the role of protein aggregation in neurodegeneration?

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

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Inhibition of macroautophagy triggers apoptosis

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Rapamycin pre-treatment protects against apoptosis

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Laforin, the most common protein mutated in Lafora disease, regulates autophagy

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A role for ubiquitin in selective autophagy

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A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

21 January 2018

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

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Huntington's disease: from pathology and genetics to potential therapies

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

21 January 2018

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Mutant dynactin in motor neuron disease.

21 January 2018

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Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS.

21 January 2018

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Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

21 January 2018

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Dynein mutations impair autophagic clearance of aggregate-prone proteins

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Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

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ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration

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The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

21 January 2018

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A block of autophagy in lysosomal storage disorders

21 January 2018

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Alzheimer's disease: genetic studies and transgenic models

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

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Autophagy failure in Alzheimer's disease--locating the primary defect

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Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

21 January 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

21 January 2018

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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Parkinson's disease: from monogenic forms to genetic susceptibility factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

21 January 2018

Mechanisms of mitophagy

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Chemical modulators of autophagy as biological probes and potential therapeutics

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy plays a protective role during zVAD-induced necrotic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Broadening the therapeutic scope for rapamycin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Lithium induces autophagy by inhibiting inositol monophosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Small molecule regulators of autophagy identified by an image-based high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Chaperone-mediated autophagy in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Mammalian autophagy: core molecular machinery and signaling regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy defends cells against invading group A Streptococcus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Escape of intracellular Shigella from autophagy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole.

21 January 2018

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CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes

21 January 2018

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Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy in cardiac myocyte homeostasis, aging, and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Ambra1 regulates autophagy and development of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.200

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22187000

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Autophagy and misfolded proteins in neurodegeneration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22187000

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22187000

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRNEUROL.2011.200

1 reference

Dimensions Publication ID

26 August 2017

0 references

1 reference