Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate. (Q36488109)

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scientific article published on 23 October 2012

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English	Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.	scientific article published on 23 October 2012

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16 February 2020

Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate (English)

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16 February 2020

Anjaneyulu Kowluru

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Abiy M Mohammed

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Khadija Syeda

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16 February 2020

Timothy Hadden

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23 October 2012

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16 February 2020

Biochemical Pharmacology

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16 February 2020

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16 February 2020

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

1 reference

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A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death

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A palmitoylation switch mechanism regulates Rac1 function and membrane organization.

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Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation

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30 September 2017

Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1.

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Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.

1 reference

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Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction

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Diagnosis and Classification of Diabetes Mellitus

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Small G proteins in islet beta-cell function

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Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

1 reference

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30 September 2017

The role for endoplasmic reticulum stress in diabetes mellitus

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The vicious cycle of apoptotic beta-cell death in type 1 diabetes

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30 September 2017

Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines

1 reference

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Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway

1 reference

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Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

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GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell

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30 September 2017

Positive modulation by Ras of interleukin-1beta-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells

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Interferon-gamma-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production

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Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4.

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NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets.

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Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells

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21 September 2018

Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase

1 reference

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Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells

1 reference

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21 September 2018

Unraveling the molecular machinery that promotes pancreatic β-cell dysfunction during oxidative stress: focus on "Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23092759

12 December 2020

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10.1016/J.BCP.2012.09.024

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16 February 2020

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16 February 2020

1 reference

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16 February 2020

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