Evaluating Drosophila p53 as a model system for studying cancer mutations (Q36492803)

14 August 2017

Evaluating Drosophila p53 as a model system for studying cancer mutations (English)

1 reference

14 August 2017

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4

Alan R Fersht

1 reference

14 August 2017

2

Andreas C Joerger

1 reference

14 August 2017

5

Ehud Gazit

1 reference

14 August 2017

Gal Herzog

1

1 reference

14 August 2017

Merav D Shmueli

series ordinal

3

1 reference

14 August 2017

Daniel Segal

series ordinal

6

1 reference

14 August 2017

language of work or name

English

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publication date

7 November 2012

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Journal of Biological Chemistry

14 August 2017

8

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based on heuristic

inferred from page(s)

published in

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14 August 2017

287

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14 August 2017

53

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14 August 2017

44330-44337

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Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

First-order rate-determining aggregation mechanism of p53 and its implications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Drosophila cancer models.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Phylogeny and function of the invertebrate p53 superfamily

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

The tumor suppressor p53: from structures to drug discovery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

p53 Research: the past thirty years and the next thirty years.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

High-throughput screening and small animal models, where are we?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Blinded by the Light: The Growing Complexity of p53

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Structural biology of the tumor suppressor p53.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Clustal W and Clustal X version 2.0

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Structural evolution of C-terminal domains in the p53 family

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Structure-function-rescue: the diverse nature of common p53 cancer mutants

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Drosophila models for cancer research.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Targeted mutagenesis by homologous recombination in D. melanogaster

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Identification and characterization of a p53 homologue in Drosophila melanogaster

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Thermodynamic stability of wild-type and mutant p53 core domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Definition of a consensus binding site for p53

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Drosophila p53 binds a damage response element at the reaper locus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531747

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

28 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

Regulation of DNA binding of p53 by its C-terminal domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

Cooperative binding of tetrameric p53 to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

Structural basis of DNA recognition by p53 tetramers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.417980

The use of light-scattering and turbidity measurements to study the kinetics of extensively aggregating proteins: alphas-casein

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23135266

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The UMD TP53 database and website: update and revisions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23135266

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.417980

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

23135266

1 reference