HIFing the brakes: therapeutic opportunities for treatment of human malignancies (Q36493913)

14 August 2017

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title

HIFing the brakes: therapeutic opportunities for treatment of human malignancies (English)

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14 August 2017

Joseph A Garcia

1

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14 August 2017

publication date

30 May 2006

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Science's STKE : signal transduction knowledge environment

14 August 2017

published in

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14 August 2017

volume

2006

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14 August 2017

issue

337

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14 August 2017

page(s)

pe25

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Purification and characterization of hypoxia-inducible factor 1

14 August 2017

cites work

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Proline hydroxylation and gene expression

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

HIF-1 and tumor progression: pathophysiology and therapeutics

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

The HIF pathway in cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Role of VHL gene mutation in human cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypox

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3372006PE25

21 January 2018

Identifiers

DOI

10.1126/STKE.3372006PE25

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14 August 2017

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