BCL-2 in the crosshairs: tipping the balance of life and death (Q36501184)

14 August 2017

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title

BCL-2 in the crosshairs: tipping the balance of life and death (English)

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14 August 2017

1

Walensky LD

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PubMed ID

16763614

14 August 2017

language of work or name

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9 June 2006

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Cell Death & Differentiation

14 August 2017

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14 August 2017

13

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14 August 2017

8

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14 August 2017

1339-1350

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401992

14 August 2017

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cites work

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Cell death: critical control points

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Axonal self-destruction and neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Role of Bcl-2 family of proteins in malignancy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Structural biology of the Bcl-2 family of proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Proapoptotic BID is an ATM effector in the DNA-damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bad-deficient mice develop diffuse large B cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Translocation of full-length Bid to mitochondria during anoikis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

A role for proapoptotic BID in the DNA-damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Life in the balance: how BH3-only proteins induce apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Humanin peptide suppresses apoptosis by interfering with Bax activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

VDAC2 inhibits BAK activation and mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Clusterin inhibits apoptosis by interacting with activated Bax

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Channel formation by antiapoptotic protein Bcl-2.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Solution structure of the antiapoptotic protein bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Solution structure of BID, an intracellular amplifier of apoptotic signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The N-terminal end of Bax contains a mitochondrial-targeting signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Involvement of the N-terminus of Bax in its intracellular localization and function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Regulated targeting of BAX to mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bax cleavage is mediated by calpain during drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Cleavage of Bax enhances its cell death function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Conformation of membrane-associated proapoptotic tBid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

NMR studies of the anti-apoptotic protein Bcl-xL in micelles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Identification of chelerythrine as an inhibitor of BclXL function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Apoptosis-based therapies for hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Paralog-selective ligands for bcl-2 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

3,6-Dibromocarbazole Piperazine Derivatives of 2-Propanol as First Inhibitors of Cytochrome c Release via Bax Channel Modulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Promoting apoptosis as a strategy for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Investigations of antisense oligonucleotides targeted against bcl-2 RNAs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401992

1 reference

14 August 2017

1 reference

PubMed ID

16763614