Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. (Q36545062)

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scientific article published on 28 September 2015

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English	Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis.	scientific article published on 28 September 2015

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scholarly article

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25 February 2020

Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis (English)

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25 February 2020

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renal cell carcinoma

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metastatic renal cell carcinoma

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10

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25 February 2020

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Da Eun Jeong

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25 February 2020

Hye Jin Jin Song

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25 February 2020

Sharon Lim

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25 February 2020

Se Jeong Jeong Lee

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Joung Eun Lim

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25 February 2020

Do-Hyun Nam

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25 February 2020

Kyeung Min Joo

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25 February 2020

Byong Chang Jeong

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Seong Soo Jeon

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25 February 2020

Hye Won Lee

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1 October 2015

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25 February 2020

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25 February 2020

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25 February 2020

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25 February 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4741748/fullTextXML

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The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma

1 reference

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30 September 2017

Anticancer Effect of AntiMalarial Artemisinin Compounds

1 reference

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Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease

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The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

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30 September 2017

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.

1 reference

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30 September 2017

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

1 reference

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30 September 2017

Alpha-smooth muscle actin (ACTA2) is required for metastatic potential of human lung adenocarcinoma

1 reference

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30 September 2017

Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma.

1 reference

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30 September 2017

Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71.

1 reference

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30 September 2017

Comprehensive molecular characterization of clear cell renal cell carcinoma

1 reference

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30 September 2017

Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

Effects of transferrin conjugates of artemisinin and artemisinin dimer on breast cancer cell lines

1 reference

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30 September 2017

Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide

1 reference

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30 September 2017

Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1.

1 reference

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30 September 2017

Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma

1 reference

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30 September 2017

Effects of artesunate on cytokinesis and G₂/M cell cycle progression of tumour cells and budding yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

Suppression of cancer cell growth by promoting cyclin D1 degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

Anticancer activities of artemisinin and its bioactive derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway.

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30 September 2017

Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate

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30 September 2017

Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma

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30 September 2017

Novel therapeutic inhibitors of the c-Met signaling pathway in cancer

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30 September 2017

The role of downstream signaling pathways of the epidermal growth factor receptor for Artesunate's activity in cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4741748

30 September 2017

High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor

1 reference

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30 September 2017

Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosis

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30 September 2017

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

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30 September 2017

Transcription-independent functions of MYC: regulation of translation and DNA replication

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30 September 2017

Enhancing the cytotoxic activity of novel targeted therapies--is there a role for a combinatorial approach?

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30 September 2017

Cancer cells survive with survivin

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30 September 2017

Artesunate derived from traditional Chinese medicine induces DNA damage and repair.

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30 September 2017

Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

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30 September 2017

Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation

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30 September 2017

Current perspectives on the mechanism of action of artemisinins

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The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer

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30 September 2017

Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells

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30 September 2017

Tumor angiogenesis and therapy

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30 September 2017

Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins.

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30 September 2017

Vascular endothelial growth factor and angiogenesis

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30 September 2017

Iron, brain ageing and neurodegenerative disorders

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30 September 2017

Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron

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30 September 2017

Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774.

1 reference

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30 September 2017

Metastatic renal cell carcinoma

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30 September 2017

The calpain system

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Tumorigenesis and the angiogenic switch

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30 September 2017

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30 September 2017

From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

Metastatic patterns of renal carcinoma: an analysis of 687 necropsies

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30 September 2017

First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases

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28 June 2018

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21 September 2018

Dihydroartemisinin induces apoptosis in human leukemia cells HL60 via downregulation of transferrin receptor expression

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21 September 2018

Dihydroartemisinin is an inhibitor of ovarian cancer cell growth

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21 September 2018

Renal-Cell Carcinoma

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21 September 2018

Ischemia leads to apoptosis--and necrosis-like neuron death in the ischemic rat hippocampus.

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21 September 2018

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21 September 2018

Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells

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https://pubmed.ncbi.nlm.nih.gov/26426994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-dependent steps in apoptotic signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/26426994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/beta-catenin pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/26426994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26426994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.18632/ONCOTARGET.5422

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Europe PubMed Central

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25 February 2020

PMC publication ID

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25 February 2020

PubMed publication ID

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Europe PubMed Central

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25 February 2020

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