Promises and challenges in developing RNAi as a research tool and therapy for neurodegenerative diseases (Q36565686)

15 August 2017

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title

Promises and challenges in developing RNAi as a research tool and therapy for neurodegenerative diseases (English)

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15 August 2017

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Xu Gang Xia

1

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15 August 2017

Hongxia Zhou

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2

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15 August 2017

Zuoshang Xu

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3

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15 August 2017

language of work or name

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1 January 2005

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Neurodegenerative Diseases

15 August 2017

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15 August 2017

2

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3-4

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15 August 2017

220-231

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Perspective: machines for RNAi

15 August 2017

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Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

21 January 2018

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

21 January 2018

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Mammalian RNAi for the masses

21 January 2018

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Nuclear export of microRNA precursors

21 January 2018

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

21 January 2018

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RNA interference in human cells is restricted to the cytoplasm

21 January 2018

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Specific and potent RNAi in the nucleus of human cells

21 January 2018

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Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

21 January 2018

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Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

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The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

21 January 2018

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Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies

21 January 2018

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A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

21 January 2018

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U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

21 January 2018

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Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.

21 January 2018

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siRNA relieves chronic neuropathic pain

21 January 2018

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Local gene knockdown in the brain using viral-mediated RNA interference.

21 January 2018

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Small interfering RNA and gene silencing in transgenic mice and rats

21 January 2018

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

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A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

21 January 2018

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Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.

21 January 2018

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An enhanced U6 promoter for synthesis of short hairpin RNA.

21 January 2018

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Germline transmission of RNAi in mice

21 January 2018

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Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells

21 January 2018

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Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

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New microRNAs from mouse and human

21 January 2018

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MicroRNA genes are transcribed by RNA polymerase II

21 January 2018

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Sequence requirements for micro RNA processing and function in human cells

21 January 2018

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siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

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Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells.

21 January 2018

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Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo

21 January 2018

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An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi

21 January 2018

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Of mice and models: improved animal models for biomedical research

21 January 2018

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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

21 January 2018

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Gene disruption by regulated short interfering RNA expression, using a two-adenovirus system.

21 January 2018

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Establishment of conditional vectors for hairpin siRNA knockdowns

21 January 2018

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Development of a tightly regulated U6 promoter for shRNA expression

21 January 2018

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Inducible, reversible, and stable RNA interference in mammalian cells

21 January 2018

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Control of siRNA expression using the Cre-loxP recombination system.

21 January 2018

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Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system.

21 January 2018

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Survey and summary: transcription by RNA polymerases I and III.

21 January 2018

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CRE recombinase-inducible RNA interference mediated by lentiviral vectors

21 January 2018

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Cre-lox-regulated conditional RNA interference from transgenes

21 January 2018

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Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination

21 January 2018

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Amyotrophic lateral sclerosis

21 January 2018

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Mechanism and treatment of motoneuron degeneration in ALS: what have SOD1 mutants told us?

21 January 2018

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Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site

21 January 2018

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

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Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature

21 January 2018

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Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

21 January 2018

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

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Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

21 January 2018

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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

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Recent developments in gene transfer: risk and ethics

21 January 2018

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Allele-specific silencing of dominant disease genes

21 January 2018

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An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase.

21 January 2018

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Loss of normal huntingtin function: new developments in Huntington's disease research

21 January 2018

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Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

21 January 2018

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Mutant genes in familial Alzheimer's disease and transgenic models

21 January 2018

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

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Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000089629

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15 August 2017

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