Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. (Q35847967)

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9 January 2020

title

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype (English)

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9 January 2020

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10

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9 January 2020

author name string

Joseph D Growney

1

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9 January 2020

Hirokazu Shigematsu

2

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9 January 2020

Zhe Li

3

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9 January 2020

Benjamin H Lee

4

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9 January 2020

Jennifer Adelsperger

5

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9 January 2020

Rebecca Rowan

6

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9 January 2020

David P Curley

7

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9 January 2020

Jeffery L Kutok

8

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9 January 2020

Koichi Akashi

9

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9 January 2020

Nancy A Speck

11

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9 January 2020

D Gary Gilliland

12

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9 January 2020

language of work or name

English

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publication date

22 March 2005

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9 January 2020

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9 January 2020

volume

106

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9 January 2020

issue

2

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9 January 2020

page(s)

494-504

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Core-binding factors in hematopoiesis and immune function

9 January 2020

cites work

1 reference

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Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells

11 July 2018

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

11 July 2018

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SCL is required for normal function of short-term repopulating hematopoietic stem cells

11 July 2018

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Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression

11 July 2018

1 reference

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Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

11 July 2018

1 reference

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Upstream and downstream targets of RUNX proteins.

11 July 2018

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RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

11 July 2018

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The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12

11 July 2018

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Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11

11 July 2018

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

11 July 2018

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In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

11 July 2018

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Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

11 July 2018

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

11 July 2018

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

11 July 2018

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Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

11 July 2018

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Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

11 July 2018

1 reference

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

11 July 2018

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The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties

11 July 2018

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

11 July 2018

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The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

11 July 2018

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Identification of clonogenic common lymphoid progenitors in mouse bone marrow

11 July 2018

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Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Mün

11 July 2018

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Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2.

11 July 2018

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

11 July 2018

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

11 July 2018

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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

11 July 2018

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The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

11 July 2018

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Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

11 July 2018

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

11 July 2018

1 reference

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

11 July 2018

1 reference

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Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia

11 July 2018

1 reference

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

11 July 2018

1 reference

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The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

11 July 2018

1 reference

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Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting

11 July 2018

1 reference

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Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

11 July 2018

1 reference

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The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

11 July 2018

1 reference

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

11 July 2018

1 reference

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Inducible gene targeting in mice

11 July 2018

1 reference

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Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.

11 July 2018

1 reference

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Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions

11 July 2018

1 reference

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Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny

11 July 2018

1 reference

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

11 July 2018

1 reference

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Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

11 July 2018

1 reference

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Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

11 July 2018

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Cbfβ is involved in maturation of all lineages of hematopoietic cells during embryogenesis except erythroid

11 July 2018

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Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

24 September 2018

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Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

24 September 2018

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Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

24 September 2018

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Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

24 September 2018

1 reference

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Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

24 September 2018

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M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH)

24 September 2018

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12 December 2020

Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse

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12 December 2020

Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials. MRC Adult Leukaemia Working Party

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12 December 2020

High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21

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12 December 2020

Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo

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12 December 2020

Cytogenetically cryptic AML1-ETO and CBFbeta-MYH11 gene rearrangements: incidence in 412 cases of acute myeloid leukaemia

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12 December 2020

Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia. A study of 235 Chinese patients in Taiwan

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12 December 2020

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis

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12 December 2020

High incidence of TEL/AML1 fusion resulting from a cryptic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan

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12 December 2020

Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials. The MRC Adult Leukaemia Working Party

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12 December 2020

Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia

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12 December 2020

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

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12 December 2020

10.1182/BLOOD-2004-08-3280

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784726%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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9 January 2020

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