The mTOR pathway in the control of protein synthesis (Q36600753)

15 August 2017

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title

The mTOR pathway in the control of protein synthesis (English)

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15 August 2017

2

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15 August 2017

Xuemin Wang

1

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15 August 2017

1 October 2006

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15 August 2017

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15 August 2017

21

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15 August 2017

362-369

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The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus

15 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Functional properties of phosphorylated elongation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Drug-eluting stents in vascular intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Cardiac hypertrophy: a matter of translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Dissociation of double-stranded polynucleotide helical structures by eukaryotic initiation factors, as revealed by a novel assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Hypoxia-induced energy stress regulates mRNA translation and cell growth

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Rheb binds and regulates the mTOR kinase

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Drosophila S6 kinase: a regulator of cell size.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Regulation of the small GTPase Rheb by amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Growing roles for the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Amino acid availability regulates p70 S6 kinase and multiple translation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00024.2006

10.1152/PHYSIOL.00024.2006

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16990457