Genes, ageing and longevity in humans: problems, advantages and perspectives. (Q36647435)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17090420%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

review article

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title

Genes, ageing and longevity in humans: problems, advantages and perspectives (English)

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21 December 2019

9

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21 December 2019

Fabiola Olivieri

2

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21 December 2019

Maurizio Cardelli

4

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21 December 2019

Aurelia Santoro

5

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21 December 2019

Michele Mishto

7

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21 December 2019

Francesco Lescai

14

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21 December 2019

Giuseppe Paolisso

17

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21 December 2019

Daniela Monti

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21 December 2019

author name string

Salvioli S

1

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21 December 2019

Marchegiani F

3

1 reference

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21 December 2019

Bellavista E

6

1 reference

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21 December 2019

Invidia L

8

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21 December 2019

Valensin S

10

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21 December 2019

Sevini F

11

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21 December 2019

Cevenini E

12

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21 December 2019

Celani L

13

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21 December 2019

Gonos E

15

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21 December 2019

Caruso C

16

1 reference

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21 December 2019

De Benedictis G

18

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21 December 2019

Franceschi C

20

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21 December 2019

language of work or name

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1 December 2006

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21 December 2019

published in

Free Radical Research

1 reference

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21 December 2019

volume

40

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21 December 2019

issue

12

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21 December 2019

page(s)

1303-1323

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Aging: a theory based on free radical and radiation chemistry

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Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies

21 January 2018

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

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21 January 2018

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Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes.

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background

21 January 2018

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21 January 2018

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Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity

21 January 2018

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Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

21 January 2018

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Cellular resistance to homocysteine: a key for longevity.

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Evidence for reduction of pro-atherosclerotic properties in platelets from healthy centenarians.

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21 January 2018

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21 January 2018

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Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

21 January 2018

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PARP-1: a regulator of genomic stability linked with mammalian longevity

21 January 2018

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Poly(ADP-Ribose) polymerase-1 in acute neuronal death and inflammation: a strategy for neuroprotection

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Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).

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p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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Primary structure polymorphism at amino acid residue 72 of human p53.

21 January 2018

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Two polymorphic variants of wild-type p53 differ biochemically and biologically

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

p53 polymorphic variants at codon 72 exert different effects on cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

p53 variants predisposing to cancer are present in healthy centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Variation in the human TP53 gene affects old age survival and cancer mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Oxidative damage and mitochondrial decay in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Role of nuclear background and in vivo environment in variable segregation behavior of the aging-dependent T414G mutation at critical control site for human fibroblast mtDNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

The organization and inheritance of the mitochondrial genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial DNA, aconitase 'wraps' it up.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

The mitochondrial theory of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Point mutations of the mtDNA control region in normal and neurodegenerative human brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Control region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial DNA variation in human populations and implications for detection of mitochondrial DNA mutations of pathological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial DNA sequence variation in human evolution and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Effects of purifying and adaptive selection on regional variation in human mtDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Analysis of European mitochondrial haplogroups with Alzheimer disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial DNA polymorphisms associated with longevity in a Finnish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Immunoproteasomes and immunosenescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Clinical phenotype of families with longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Genetic contribution to biological aging: the Framingham Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Parental longevity and mortality amongst Japanese men and women: the JACC Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Life-long sustained mortality advantage of siblings of centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Inflamm-aging. An evolutionary perspective on immunosenescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

The network and the remodeling theories of aging: historical background and new perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

The unusual genetics of human longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

The interleukin-6 −174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Cardiovascular Advantages Among the Offspring of Centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Genetic Influence on Inflammation Variables in the Elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136

Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600917136