Sirtuins as potential targets for metabolic syndrome (Q36682665)

15 August 2017

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title

Sirtuins as potential targets for metabolic syndrome (English)

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15 August 2017

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Leonard Guarente

1

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PubMed ID

17167475

15 August 2017

language of work or name

English

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publication date

1 December 2006

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15 August 2017

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15 August 2017

444

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15 August 2017

7121

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15 August 2017

868-874

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https://scigraph.springernature.com/pub.10.1038/nature05486

15 August 2017

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cites work

Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Food, reproduction and L'ongevity: Is the extended lifespan of calorie-restricted animals an evolutionary adaptation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Suppression of adenocarcinoma by the immunological consequences of calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Dietary restriction benefits learning and motor performance of aged mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Extrachromosomal rDNA circles--a cause of aging in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Asymmetric inheritance of oxidatively damaged proteins during cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

HST2 mediates SIR2-independent life-span extension by calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Calorie restriction extends yeast life span by lowering the level of NADH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Sir2-independent life span extension by calorie restriction in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Origins of blood acetate in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Metabolic control through the PGC-1 family of transcription coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Management of cellular energy by the AMP-activated protein kinase system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Activating AMP-activated protein kinase without AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

Increase in activity during calorie restriction requires Sirt1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05486

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NATURE05486

1 reference

PubMed ID

17167475

Dimensions Publication ID

15 August 2017

0 references

1 reference

PubMed ID

17167475