Unraveling the complex regulation of stem cells: implications for aging and cancer (Q36717968)

15 August 2017

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title

Unraveling the complex regulation of stem cells: implications for aging and cancer (English)

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15 August 2017

Oakley EJ

1

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PubMed ID

17252019

15 August 2017

Van Zant G

series ordinal

2

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15 August 2017

25 January 2007

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15 August 2017

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15 August 2017

21

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15 August 2017

612-621

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15 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2404530

15 August 2017

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cites work

Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1.

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

MicroRNAs: critical regulators of development, cellular physiology and malignancy

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

“Fertile” Intestine Nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Supralethal whole body irradiation and isologous marrow transplantation in man.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

A stem cell molecular signature

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

"Stemness": transcriptional profiling of embryonic and adult stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Cell intrinsic alterations underlie hematopoietic stem cell aging.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Chromatin signatures of pluripotent cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Polycomb complexes repress developmental regulators in murine embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Control of developmental regulators by Polycomb in human embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNAs: genomics, biogenesis, mechanism, and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The use of RNAs complementary to specific mRNAs to regulate the expression of individual bacterial genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNAs modulate hematopoietic lineage differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNA profiling of the murine hematopoietic system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The aging of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Genetic regulation of primitive hematopoietic stem cell senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Epigenetic differences arise during the lifetime of monozygotic twins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The fundamental role of epigenetic events in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The epigenetic progenitor origin of human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Stem cell division is regulated by the microRNA pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNAs as oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Chromatin modification and epigenetic reprogramming in mammalian development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The emerging role of epigenetics in cellular and organismal aging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Translating the Histone Code

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Chromatin silencing and activation by Polycomb and trithorax group proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Cancer epigenetics comes of age

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Homoeosis in Drosophila: a description of the Polycomb lethal syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

A gene complex controlling segmentation in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Polycombing the genome: PcG, trxG, and chromatin silencing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Polycomb complexes and silencing mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Stabilization of chromatin structure by PRC1, a Polycomb complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The INK4A/ARF locus and its two gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Applying the principles of stem-cell biology to cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Stem cells, cancer, and cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

DNA methylation in aging of mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Stem cells, aging, and cancer: inevitabilities and outcomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Cancer and aging: a model for the cancer promoting effects of the aging stroma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

A mouse model of Werner Syndrome: what can it tell us about aging and cancer?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The Werner syndrome protein is a DNA helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

c-Myc-regulated microRNAs modulate E2F1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

A microRNA polycistron as a potential human oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNA maturation: stepwise processing and subcellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The Drosha-DGCR8 complex in primary microRNA processing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNA function in animal development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Dicer is required for embryonic angiogenesis during mouse development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The microRNA-producing enzyme Dicer1 is essential for zebrafish development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Characterization of Dicer-deficient murine embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Aberrant T cell differentiation in the absence of Dicer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Dicer is essential for mouse development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Human embryonic stem cells express a unique set of microRNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Embryonic stem cell-specific MicroRNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNAs: regulators of gene expression and cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

miR-15 and miR-16 induce apoptosis by targeting BCL2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

A microRNA cluster as a target of genomic amplification in malignant lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Sizing up miRNAs as cancer genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

MicroRNA expression profiles classify human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Nonrestrictive developmental regulation of microRNA gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

The role of microRNAs in normal hematopoiesis and hematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

miRNAs, cancer, and stem cell division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Aging and cancer: issues of basic and clinical science

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Chromatin dynamics at DNA replication, transcription and repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

ATP-dependent chromatin-remodeling complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

DNA methylation patterns and epigenetic memory

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404530

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2404530

1 reference

PubMed ID

17252019

Dimensions Publication ID

15 August 2017

0 references

1 reference

PubMed ID

17252019