The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. (Q36723910)

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25 December 2019

review article

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title

The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds (English)

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25 December 2019

2

Danyelle M Townsend

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25 December 2019

4

Kenneth D Tew

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25 December 2019

3

Vladimir Beljanski

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25 December 2019

1

Jody T Mack

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25 December 2019

language of work or name

English

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publication date

1 January 2007

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25 December 2019

published in

Current Drug Metabolism

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25 December 2019

volume

8

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25 December 2019

issue

1

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25 December 2019

page(s)

47-57

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HLA class I deficiencies due to mutations in subunit 1 of the peptide transporter TAP1.

25 December 2019

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High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

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Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2

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Increased plasma HDL-cholesterol and apo A-I in breast cancer patients undergoing adjuvant tamoxifen therapy

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Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2.

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Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages

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Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2)

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Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells

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Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease

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Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome

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Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

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Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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Alzheimer's disease: molecular concepts and therapeutic targets

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

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12 December 2020

Cholesterol and Alzheimer's disease: is there a link?

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12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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12 December 2020

New frontiers in Alzheimer's disease genetics

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12 December 2020

ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells

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12 December 2020

Identification of sterol-independent regulatory elements in the human ATP-binding cassette transporter A1 promoter: role of Sp1/3, E-box binding factors, and an oncostatin M-responsive element

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Cl(-)-dependent HCO3- transport by cystic fibrosis transmembrane conductance regulator.

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12 December 2020

Cholesterol, A beta and Alzheimer's disease

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12 December 2020

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

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12 December 2020

Increased ABCA1 activity protects against atherosclerosis.

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12 December 2020

Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8

1 reference

12 December 2020

ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination

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12 December 2020

Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1.

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12 December 2020

ABCA2: a candidate regulator of neural transmembrane lipid transport

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12 December 2020

Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases.

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12 December 2020

Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism

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12 December 2020

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors

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12 December 2020

ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease

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12 December 2020

Alzheimer's disease: the cholesterol connection

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12 December 2020

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

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Dietary meat, dairy products, fat, and cholesterol and pancreatic cancer risk in a prospective study

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12 December 2020

Of cancer and cholesterol: studies elucidate anticancer mechanisms of statins

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12 December 2020

ABC Transporters: From Microorganisms to Man

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12 December 2020

Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy

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12 December 2020

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

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12 December 2020

Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization

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12 December 2020

LDL receptor-dependent polyunsaturated fatty acid transport and metabolism

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12 December 2020

Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells

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12 December 2020

Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS.

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P-glycoprotein: from genomics to mechanism.

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12 December 2020

Cholesterol and prostate cancer

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12 December 2020

Alzheimer's disease: one disorder, too many genes?

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12 December 2020

The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function

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12 December 2020

Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition

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12 December 2020

Use of cholesterol drugs may decrease breast cancer risk

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12 December 2020

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

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12 December 2020

Neurodegenerative diseases and oxidative stress

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12 December 2020

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages

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12 December 2020

Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

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12 December 2020

Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration

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12 December 2020

Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus

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12 December 2020

Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation.

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12 December 2020

Association of ABCA2 expression with determinants of Alzheimer's disease

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12 December 2020

The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.

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Genetic mechanisms of surfactant deficiency

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12 December 2020

Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells

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12 December 2020

How does protein architecture facilitate the transduction of ATP chemical-bond energy into mechanical work? The cases of nitrogenase and ATP binding-cassette proteins

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12 December 2020

ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities

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12 December 2020

ABC transporter ABCA3 is expressed in acute myeloid leukemia blast cells and participates in vesicular transport

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12 December 2020

Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.

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12 December 2020

ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease

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12 December 2020

Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner

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12 December 2020

Tumour stem cells and drug resistance

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12 December 2020

Lysosomes as targets for cancer therapy

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12 December 2020

Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve

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12 December 2020

ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms

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12 December 2020

ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease

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12 December 2020

High-density lipoproteins and ATP-binding cassette transporters as targets for cardiovascular drug therapy.

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12 December 2020

The genetics of ATP-binding cassette transporters

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12 December 2020

ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain

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12 December 2020

Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells

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12 December 2020

Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease

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12 December 2020

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

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12 December 2020

Multiple sequence alignment with hierarchical clustering

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12 December 2020

Arachidonic acid metabolism

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12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

1 reference

12 December 2020

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability

1 reference

12 December 2020

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

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12 December 2020

APOE is a major susceptibility gene for Alzheimer's disease

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12 December 2020

The causes and prevention of cancer

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12 December 2020

The oxidation hypothesis of atherosclerosis

1 reference

12 December 2020

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

1 reference

12 December 2020

Cloning of two novel ABC transporters mapping on human chromosome 9

1 reference

12 December 2020

Tamoxifen and toremifene lower serum cholesterol by inhibition of delta 8-cholesterol conversion to lathosterol in women with breast cancer.

1 reference

12 December 2020

Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters

1 reference

12 December 2020

Mutations in the adrenoleukodystrophy gene

1 reference

12 December 2020

The physiological function of drug-transporting P-glycoproteins

1 reference

12 December 2020

Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukemia.

1 reference

12 December 2020

Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells.

1 reference

12 December 2020

Evolutionary relationships among ABC transporters

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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12 December 2020

Alzheimer's disease: genetic studies and transgenic models

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12 December 2020

10.2174/138920007779315044

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17266523%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17266523%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

17266523

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