Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue (Q36725815)

15 August 2017

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue (English)

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15 August 2017

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12 June 2020

Dudley W Lamming

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12 June 2020

author name string

Sarmistha Mukherjee

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12 June 2020

Lan Ye

3

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12 June 2020

David W Frederick

4

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12 June 2020

Megan Kissig

5

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12 June 2020

James G Davis

6

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12 June 2020

Patrick Seale

8

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12 June 2020

Joseph A Baur

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12 June 2020

language of work or name

English

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publication date

8 February 2016

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15 August 2017

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12 June 2020

volume

65

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12 June 2020

page(s)

927-941

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12 June 2020

issue

4

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Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.

12 June 2020

cites work

1 reference

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Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

30 September 2017

1 reference

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Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes

30 September 2017

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Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

30 September 2017

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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

30 September 2017

1 reference

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Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

30 September 2017

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Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

30 September 2017

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Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

30 September 2017

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Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

30 September 2017

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Brown and beige fat: development, function and therapeutic potential

30 September 2017

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Fat cells directly sense temperature to activate thermogenesis

30 September 2017

1 reference

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Duration of rapamycin treatment has differential effects on metabolism in mice

30 September 2017

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

30 September 2017

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β3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation

30 September 2017

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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

30 September 2017

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Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling.

30 September 2017

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

30 September 2017

1 reference

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

30 September 2017

1 reference

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Insulin resistance, hyperglycemia, and atherosclerosis

30 September 2017

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mTOR links incretin signaling to HIF induction in pancreatic beta cells

30 September 2017

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cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

30 September 2017

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Transcriptional control of adipose lipid handling by IRF4

30 September 2017

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

30 September 2017

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Nonshivering thermogenesis and its adequate measurement in metabolic studies

30 September 2017

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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

30 September 2017

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cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

30 September 2017

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Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

30 September 2017

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

30 September 2017

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

30 September 2017

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30 September 2017

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PRDM16 controls a brown fat/skeletal muscle switch

30 September 2017

1 reference

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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

30 September 2017

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Developmental origin of fat: tracking obesity to its source.

30 September 2017

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

30 September 2017

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30 September 2017

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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

30 September 2017

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Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

30 September 2017

1 reference

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Energy metabolism during cold exposure

30 September 2017

1 reference

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mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806661

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806661

Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4806661

Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs.

5 September 2018

1 reference

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Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients.

5 September 2018

1 reference

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Hypertriglyceridemia in renal transplant recipients treated with sirolimus

5 September 2018

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12 December 2020

β3-Adrenergic Receptors on White and Brown Adipocytes Mediate β3-Selective Agonist-induced Effects on Energy Expenditure, Insulin Secretion, and Food Intake

1 reference

12 December 2020

Interactions of cold exposure and starvation on glucose tolerance and insulin response

1 reference

12 December 2020

Sirolimus therapy predisposes to new-onset diabetes mellitus after renal transplantation: a long-term analysis of various treatment regimens

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB15-0502

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858361%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858361%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference