Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction (Q28304066)

2

0 references

Clinton M Astle

3

0 references

Elizabeth Fernandez

4

0 references

Kevin Flurkey

5

0 references

Melissa Han

6

0 references

Martin A Javors

7

0 references

Xinna Li

8

0 references

Nancy L Nadon

9

0 references

James F Nelson

10

0 references

Scott Pletcher

11

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Adam B Salmon

12

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Zelton Dave Sharp

13

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Sabrina Van Roekel

14

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Lynn Winkleman

15

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Randy Strong

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

16

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language of work or name

English

0 references

publication date

June 2014

0 references

published in

Aging Cell

0 references

volume

13

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page(s)

468-77

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issue

3

0 references

cites work

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

7 April 2017

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Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.

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Rapamycin extends murine lifespan but has limited effects on aging

29 September 2017

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Late-life rapamycin treatment reverses age-related heart dysfunction.

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Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

29 September 2017

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Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

29 September 2017

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Probing the relationship between insulin sensitivity and longevity using genetically modified mice

29 September 2017

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Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

29 September 2017

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Rapamycin slows aging in mice

29 September 2017

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Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice

29 September 2017

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Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses

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Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice

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Rapamycin extends maximal lifespan in cancer-prone mice

29 September 2017

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

29 September 2017

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mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

29 September 2017

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Lifespan extension in genetically modified mice

29 September 2017

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Sex differences in the expression of hepatic drug metabolizing enzymes

29 September 2017

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29 September 2017

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29 September 2017

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

29 September 2017

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29 September 2017

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Low methionine ingestion by rats extends life span

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Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice.

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https://api.crossref.org/works/10.1111%2FACEL.12194

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12194

Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12194

Ageing: A midlife longevity drug?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12194

T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12194

Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12194

Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12194

Statistical methods for testing effects on “maximum lifespan”

21 January 2018

1 reference

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Genetic loci that influence cause of death in a heterogeneous mouse stock

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24341993

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-lived dwarf mice: are bile acids a longevity signal?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24341993

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/ACEL.12194

1 reference

554414

554414

1 reference

1 reference

1 reference